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> EGFR Human Gene Knockout Kit (CRISPR)

EGFR Human Gene Knockout Kit (CRISPR)

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EGFR Human Gene Knockout Kit (CRISPR)

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SKU
KN214877RB
EGFR - human gene knockout kit via CRISPR, HDR mediated
 

Other products for "EGFR or NM_005228"

Specifications
Product Data
Format 2 gRNA vectors, 1 RFP-BSD donor, 1 scramble control
Vector RFP-BSD
Target Symbol EGFR
Locus ID 1956
Components

KN214877G1, EGFR gRNA vector 1 in pCas-Guide CRISPR vector

KN214877G2, EGFR gRNA vector 2 in pCas-Guide CRISPR vector

KN214877RBD, donor DNA containing left and right homologous arms and RFP-BSD functional cassette.

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_005228, NM_201282, NM_201283, NM_201284, NM_001346897, NM_001346898, NM_001346899, NM_001346900, NM_001346941
UniProt ID P00533
Synonyms ERBB; ERBB1; HER1; mENA; NISBD2; PIG61
Summary The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation. Mutations in this gene are associated with lung cancer. EGFR is a component of the cytokine storm which contributes to a severe form of Coronavirus Disease 2019 (COVID-19) resulting from infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). provided by RefSeq, Jul 2020
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Product Manuals
FAQs
    FAQ for CRISPR Products
SDS
SKU Description Size
GA101355 EGFR CRISPRa kit - CRISPR gene activation of human epidermal growth factor receptor 1 kit
KN214877 EGFR - human gene knockout kit via CRISPR, HDR mediated 1 kit
KN214877BN EGFR - human gene knockout kit via CRISPR, HDR mediated 1 kit
KN214877LP EGFR - human gene knockout kit via CRISPR, HDR mediated 1 kit
KN414877 EGFR - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.