DNMT3B Recombinant Protein
Referencia OPCD00858-10UG
embalaje : 10ug
Marca : Aviva Systems Biology
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Teléfono : +1 850 650 7790
DNMT3B Recombinant Protein (OPCD00858)
| Datasheets/Manuals | Printable datasheet for DNMT3B Recombinant Protein (OPCD00858) |
|---|
| Predicted Species Reactivity | Mouse|Mus musculus |
|---|---|
| Product Format | Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose. |
| Host | E.coli |
| Conjugation | Unconjugated |
| Application | Ctrl (+), SDS-PAGE, WB |
| Additional Information | Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method) |
| :: | Residues: Ile581-Glu859 |
| Reconstitution and Storage | 2°C to 8°C|-80°C |
| Concentration | 200 ug/mL (prior to lyoph) |
| Purity | > 95% |
| Source | E.coli |
| Tag | N-terminal His Tag |
| Gene Symbol | Dnmt3b |
|---|---|
| Gene Full Name | DNA methyltransferase 3B |
| Alias Symbols | DNA (cytosine-5)-methyltransferase 3B;DNA methyltransferase MmuIIIB;DNA MTase MmuIIIB;MmuIIIB. |
| NCBI Gene Id | 13436 |
| Protein Name | DNA (cytosine-5)-methyltransferase 3B |
| Description of Target | Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing. In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Function as transcriptional corepressor by associating with ZHX1 (By similarity). Required for DUX4 silencing in somatic cells (By similarity). |
| Uniprot ID | O88509 |
| Protein Accession # | NP_001003960.2 |
| Nucleotide Accession # | NM_001003960.4 |
| Protein Size (# AA) | Ile581~Glu859 |
| Molecular Weight | 28kDa |
