Dnmt3a Antibody
Referencia OAAB07267
embalaje : 400ul
Marca : Aviva Systems Biology
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Teléfono : +1 850 650 7790
Dnmt3a Antibody (OAAB07267)
| Datasheets/Manuals | Printable datasheet for Dnmt3a Antibody (OAAB07267) |
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| Predicted Species Reactivity | Chicken|Human|Mouse|Rat |
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| Product Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Clonality | Polyclonal |
| Isotype | Ig |
| Host | Rabbit |
| Application | IHC-P,WB |
| Additional Information | Precautions: Dnmt3a Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| :: | Function: Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZNF238. Can actively repress transcription through the recruitment of HDAC activity (By similarity) |
| :: | Cellular Location: Nucleus. Cytoplasm. Note=Accumulates in the major satellite repeats at pericentric heterochromatin (By similarity) Tissue Location: Highly expressed in fetal tissues, skeletal muscle, heart, peripheral blood mononuclear cells, kidney, and at lower levels in placenta, brain, liver, colon, spleen, small intestine and lung |
| Reconstitution and Storage | Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Immunogen | This Dnmt3a antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 457-486 amino acids from human Dnmt3a. |
| Predicted Homology Based on Immunogen Sequence | Human; Mouse; Rat |
| Concentration | Approximately 0.5mg/ml. Actual concentration varies with each lot. |
| Application Info | WB: 1:1000 IHC-P: 1:50~100 |
| Gene Symbol | DNMT3A |
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| Alias Symbols | cysteine methyltransferase DNMT3A, DNA (cytosine-5-)-methyltransferase 3 alpha, DNA (cytosine-5)-methyltransferase 3A, DNA cytosine methyltransferase 3A2, DNA methyltransferase 3A, DNA methyltransferase HsaIIIA, DNA methyltransferase MmuIIIA, DNA MTase HsaIIIA, DNA MTase MmuIIIA, DNMT3A2, HESJAS, M.HsaIIIA, MmuIIIA, TBRS. |
| NCBI Gene Id | 13435|1788|421991|444984 |
| Protein Name | DNA (cytosine-5)-methyltransferase 3A|DNA (cytosine-5)-methyltransferase 3A isoform a [Homo sapiens]|DNA (cytosine-5)-methyltransferase 3A isoform b [Homo sapiens]|DNA (cytosine-5)-methyltransferase 3A isoform c [Homo sapiens] |
| Description of Target | Required for genome-wide de novo methylation and is essential for development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. Acts as a transcriptional corepressor for ZNF238. Can actively repress transcription through the recruitment of HDAC activity (By similarity).|Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Can actively repress transcription through the recruitment of HDAC activity (By similarity).|Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity. |
| Uniprot ID | O88508|Q1LZ53|Q4W5Z4|Q9Y6K1 |
| Protein Accession # | https://www.ncbi.nlm.nih.gov/protein/NP_072046.2,NP_715640.2,NP_783328.1,NP_783329.1 |
| Molecular Weight | 101858 |