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DL-Glyceraldehyde [56-82-6]

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Referencia NB-64-29144-1mL

embalaje : 1mLx10mM(inDMSO)

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Teléfono : +1 850 650 7790

Marca : Neo Biotech

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Teléfono : +1 850 650 7790

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DL-Glyceraldehyde

(Synonyms: Glyceric aldehyde) Copy Product Info

Synonyms: Glyceric aldehyde

Catalog No. T4918 Copy Product Info

DL-Glyceraldehyde (Glyceric aldehyde) is produced from the action of the enzyme glyceraldehyde dehydrogenase, which converts glycerol to glyceraldehyde using NADP as a cofactor. When present at sufficiently high levels, DL-Glyceraldehyde can be a cytotoxin and a mutagen. A cytotoxin is a compound that kills cells. A mutagen is a compound that causes mutations in DNA. DL-Glyceraldehyde is a highly reactive compound that can modify and cross-link proteins. DL-Glyceraldehyde modified proteins appear to be cytotoxic, depress intracellular glutathione levels, and induce reactive oxygen species (ROS) production (PMID: 14981296 ). DL-Glyceraldehyde has been shown to cause chromosome damage to human cells in culture and is mutagenic in the Ames bacterial test.

Cas No. 56-82-6

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:90%

Appearance:Solid

Color:White

Product Introduction

Bioactivity

Description	DL-Glyceraldehyde (Glyceric aldehyde) is produced from the action of the enzyme glyceraldehyde dehydrogenase, which converts glycerol to glyceraldehyde using NADP as a cofactor. When present at sufficiently high levels, DL-Glyceraldehyde can be a cytotoxin and a mutagen. A cytotoxin is a compound that kills cells. A mutagen is a compound that causes mutations in DNA. DL-Glyceraldehyde is a highly reactive compound that can modify and cross-link proteins. DL-Glyceraldehyde modified proteins appear to be cytotoxic, depress intracellular glutathione levels, and induce reactive oxygen species (ROS) production (PMID: 14981296 ). DL-Glyceraldehyde has been shown to cause chromosome damage to human cells in culture and is mutagenic in the Ames bacterial test.
Targets & IC50	Aldose reductase:10 nM(Human)
Synonyms	Glyceric aldehyde

Chemical Properties

Molecular Weight	90.08
Formula	C₃H₆O₃
Cas No.	56-82-6
Smiles	C(CO)(C=O)O
Relative Density.	1.593 g/cm3 at -5℃

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (2775.31 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (11.1 mM), Sonication is recommended.

10% DMSO+90% Saline: 10 mg/mL (111.01 mM), Solution.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	11.1012 mL	55.5062 mL	111.0124 mL	555.0622 mL
5 mM	2.2202 mL	11.1012 mL	22.2025 mL	111.0124 mL
10 mM	1.1101 mL	5.5506 mL	11.1012 mL	55.5062 mL
20 mM	0.5551 mL	2.7753 mL	5.5506 mL	27.7531 mL
50 mM	0.2220 mL	1.1101 mL	2.2202 mL	11.1012 mL
100 mM	0.1110 mL	0.5551 mL	1.1101 mL	5.5506 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

DL-GlyceraldehydeDLGlyceraldehydeDL GlyceraldehydeAldose reductase

Related Tags: DL-Glyceraldehyde chemical structure | DL-Glyceraldehyde formula | DL-Glyceraldehyde molecular weight