dGTP [2564-35-4]
Referencia NB-64-27571-5mg
embalaje : 5mg
Marca : Neo Biotech
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Teléfono : +1 850 650 7790
dGTP (Synonyms: 2'-Deoxyguanosine-5'-triphosphate)
Catalog No. T40192 Copy Product Info
Purity: 99.64%
dGTP (2'-Deoxyguanosine-5'-triphosphate) is a guanosine nucleotide highly susceptible to oxidative damage, resulting in 8-O-GDP, 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.
dGTP
Copy Product InfoSynonyms 2'-Deoxyguanosine-5'-triphosphate
dGTP (2'-Deoxyguanosine-5'-triphosphate) is a guanosine nucleotide highly susceptible to oxidative damage, resulting in 8-O-GDP, 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.
Cas No. 2564-35-4
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Purity:99.64%
Appearance:Solid
Color:White
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Product Introduction
dGTP AI Summary
dGTP exhibits diverse bioactivities and stability profiles under various conditions. In human blood serum at 37 degrees Celsius, it has a short half-life of 0.3 hours, whereas in a phosphate buffer of pH 7.5, the half-life extends beyond 24 hours, indicating significant stability in this environment. Enzymatic kinetic studies show a Vmax of 13.1 pM U^-1 min^-1 and a Km of 62000.0 nM, yielding an efficiency ratio of 0.211. The compound demonstrates polymerizing activity with both exonuclease-deficient human recombinant DNA polymerase gamma E200A mutant and HSV1 DNA polymerase UL42 D368A mutant, with comparable Kd values of 800.0 nM, although the polymerization constant K/Kd ratio is higher for the HSV1 mutant. Additionally, dGTP acts on HIV1 reverse transcriptase, showing an activity rate of 7.5 /s and a binding affinity with a Kd of 4200.0 nM. Its inhibition efficiency for HIV1 reverse transcriptase is highlighted by a Vmax of 28.81 pmol/min and a Km of 540.0 nM, with a remarkably high efficiency ratio of Vmax/Km at 53.4 x 10^6/min. Furthermore, it maintains stability against dephosphorylation with a half-life of 1.0 hour. These multifaceted properties highlight the potential of dGTP in various biochemical and pharmacological applications..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | dGTP (2'-Deoxyguanosine-5'-triphosphate) is a guanosine nucleotide highly susceptible to oxidative damage, resulting in 8-O-GDP, 8-O-dGTP, 8-O-GTP, and 8-O-dGTP. |
| Synonyms | 2'-Deoxyguanosine-5'-triphosphate |
| Molecular Weight | 507.18 |
| Formula | C10H16N5O13P3 |
| Cas No. | 2564-35-4 |
| Smiles | O=C1C2=C(N(C=N2)[C@@H]3O[C@H](COP(OP(OP(=O)(O)O)(=O)O)(=O)O)[C@@H](O)C3)NC(N)=N1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility Information | DMSO: Slightly soluble  |