Cyanocobalamin (Vitamin B12)

Referencia C8400-1g

embalaje : 1g

Marca : US Biological

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C8400 Cyanocobalamin (Vitamin B12)

Grade
Cell Culture Grade
Shipping Temp
RT
Storage Temp
4°C

Prototype of the family of naturally occurring cobalt coordination compounds knows as corrinoids. Analogs of vitamin B12 which differ only in the β-ligand of the cobalt are termed cobalamins. Synthesized almost exclusively by bacteria. Dietary sources include fish, meat, liver, and dairy products; plants have little or no cobalamins. Converted by the body into its bioactive forms, methylcobalamin and cobamamide, which serve as enzyme cofactors. Severe deficiency may result in megaloblastic anemia and/or neurological impairment.

Synonyms:
5,6-Dimethyl-1-(3-O-phosphono-α-D-ribofuranosyl)-1H-benzimidazole Monoester Cobinamide Cyanide Inner Salt; 5,6-Dimethylbenzimidazolyl Cyanocobamide; 5,6-Dimethylbenzimidazolyl-Co-cyanocobamide; Anacobin; Antipernicin; Apikobal; B-Twelve; B-Twelve Ora; Bedodeka; Bedoz; Behepan; Berubi; Berubigen; Dobetin; Docemine; Docibin; Poyamin; Rebramin; Redamina; Vitarubin; Vitral

CAS No:
68-19-9

Molecular Formula:
C63H88CoN14O14P

Molecular Weight:
1355.38

Purity:
≥97%

Appearance:
Dark red crystalline powder

Identification:
Conforms to USP reference

Loss on Drying:
≤10%

Residual Solvents (Acetone):
≤0.5%

Psuedo Cyanocobalamin:
Conforms to USP

Total Plate Count:
≤1000cfu/g

Yeast and Mold:
≤100cfu/g

E. coli:
Negative

Meets or exceeds USP specifications

Applications
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. ||Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.
References
US Biological reference:|Chan W., et al. 2017. Cobalamin-Associated Superoxide Scavenging in Neuronal Cells Is a Potential Mechanism for Vitamin B12-Deprivation Optic Neuropathy. Am J Pathol. pii: S0002-9440(17)30324-3. doi: 10.1016/j.ajpath.2017.08.032. [Epub ahead of print].|1. Rickes, et al., Science, 107, 396 (1948)|2. Kirschbaum, J., et al., Anal. Profiles Drug Subs., 10, 183 (1981)|3. Grasbeck, R., et al., Clin. Biochem., 17, 99 (1984)|4. Chan W., et al. 2017. Am J Pathol. pii: S0002-9440(17)30324-3. doi: 10.1016/j.ajpath.2017.08.032. [Epub ahead of print].

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