embalaje : 100ug
Teléfono : +1 850 650 7790
Synonyms: X 4357B, Antibiotic X 4357B
| Description | Concanamycin A (Folimycin), a polycyclic lactone antibiotic, is a selective inhibitor of vacuolar H+-ATPase (V-ATPase) and lysosomal acidification, and can be used to study inflammation.Concanamycin A enhances the immune clearance of infected progenitor cells by cytotoxic T lymphocytes, and inhibits Nef et al. from different branches of HIV and simian immunodeficiency virus. Concanamycin A enhances immune clearance of cytotoxic T lymphocytes from infected progenitor cells, inhibits the Nef allele from different branches of HIV and simian immunodeficiency virus, and can be used to study HIV infection. |
| In vitro | In CD8+ cytotoxic T lymphocytes (CTLs), Concanamycin A (100 nM; 0, 4, 8, 12, 16, 20 hours) induced rapid cell death instead of apoptosis at 20 hours, without observed nuclear condensation[2]. |
| In vivo | In wild type mice, Concanamycin A (15 mg/kg; intravenous injection at 0, 10, or 24 hours prior to sacrifice) resulted in significant liver injury, as demonstrated by increased serum transaminase levels, inflammatory cell infiltrate, hepatocyte apoptosis, and elevated expression of several cytokines including interleukin 4 (IL4) and interferon gamma (IFNγ) at 10 and 24 hours following administration[5]. |
| Synonyms | X 4357B, Antibiotic X 4357B |
| Molecular Weight | 866.09 |
| Formula | C46H75NO14 |
| Cas No. | 80890-47-7 |
| Smiles | 23[C@@]1(C[C@@H](O)[C@H](OC(N)=O)[C@@H](C)O1)O[C@@H]1C[C@@](O)(O[C@H](\C=C\C)[C@H]1C)[C@@H](C)[C@H](O)[C@H](C)[C@@]1(23)OC(=O)\C(OC)=C\C(\C)=C\[C@@H](C)[C@H](O)[C@@H](CC)[C@H](O)[C@H](C)C\C(C)=C\C=C\[C@@H]1OC |
| Relative Density. | 1.20 g/cm3 (Predicted) |
| Storage | Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||
| Solubility Information | DMSO: 8 mg/mL (9.24 mM), Sonication is recommended. Methanol: 8 mg/mL (9.24 mM), Sonication and heating are recommended. | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO/Methanol
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
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