Cholic Acid [81-25-4]
Referencia NB-64-18522-500mg
embalaje : 500mg
Marca : Neo Biotech
Contact local distributor :
Teléfono : +1 850 650 7790
Cholic Acid (Synonyms: Colalin, Cholate, Cholanic acid)
Catalog No. T2963 Copy Product Info
Purity: 99.92%
Cholic Acid (Cholate) is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. Cholic acid facilitates fat absorption and cholesterol excretion.
Cholic Acid
Copy Product InfoSynonyms Colalin, Cholate, Cholanic acid
Cholic Acid (Cholate) is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. Cholic acid facilitates fat absorption and cholesterol excretion.
Cas No. 81-25-4
Product Introduction
Cholic Acid AI Summary
Cholic Acid exhibits a wide range of bioactivities. It shows a binding affinity with a binding constant of 900.0 Kb M^-1 toward cyclodextrin-conjugated peptides (with pyrene) at 25 degrees Celsius, also demonstrating a change in sensitivity of 0.008 towards the same peptide under identical conditions. It inhibits Na+-dependent [3H]taurocholate uptake in rabbit ileal brush border membrane vesicles with an IC25 of 40.0 µM, IC50 of 83,000.0 nM, and IC75 of 152.0 µM. It also exhibits antibacterial activity against various strains of Escherichia coli, with MIC values ranging from 4.0 to 16,000.0 µg/mL. Furthermore, Cholic Acid acts as an agonist at human TGR5, with an EC50 of 13,600.0 nM and an efficacy of 101.0% relative to lithocholic acid. It also modulates human MRP2-mediated estradiol-17-beta-glucuronide transport in Sf9 cells with an activity level of 112.0% relative to control. It demonstrates antifungal activity with MIC values >128.0 µg/mL for multiple fungi and antibacterial activity against Staphylococcus aureus with a MIC >128.0 µg/mL. The compound shows both agonist and antagonist activities at VDR-LBD and has significant bioactivity against SARS-CoV-2 induced cytotoxicity in several cell models, demonstrating inhibition rates ranging from -0.09% to 6.09% at 10 µM. Additionally, it inhibits HDAC6 and PDE3A and exerts cytotoxic effects on various human cancer cell lines with IC50 values greater than 200,000.0 nM. Cholic Acid is characterized by high water solubility, moderate binding affinity to albumin, and complex effects on cell viability and protein stability across different domains..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Cholic Acid (Cholate) is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. Cholic acid facilitates fat absorption and cholesterol excretion. |
| Synonyms | Colalin, Cholate, Cholanic acid |
| Molecular Weight | 408.57 |
| Formula | C24H40O5 |
| Cas No. | 81-25-4 |
| Smiles | O[C@H]1[C@]2([C@]3([C@@](C)([C@@]([C@@H](CCC(O)=O)C)(CC3)04)[C@@H](O)C[C@@]2([C@]4(C)[C@](C1)(C[C@H](O)CC4)04)04)04)04 |
| Relative Density. | 1.128 g/cm3. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 175 mg/mL (428.32 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.9 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||||||||||||||||||||||