Cephalosporin C zinc salt [59143-60-1]
Referencia NB-64-39523-10mg
embalaje : 10mg
Marca : Neo Biotech
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Teléfono : +1 850 650 7790
Cephalosporin C zinc salt
Catalog No. T7142 Copy Product Info
Purity: 99.14%
Cephalosporin C zinc salt was a potent inhibitor of SAMHD1 (IC50 : 1.1 ± 0.1 μM), and this inhibition was largely attributable to the presence of zinc.
Cephalosporin C zinc salt
Copy Product InfoCephalosporin C zinc salt was a potent inhibitor of SAMHD1 (IC50 : 1.1 ± 0.1 μM), and this inhibition was largely attributable to the presence of zinc.
Cas No. 59143-60-1
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Purity:99.14%
Appearance:Solid
Color:White
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Product Introduction
Cephalosporin C zinc salt AI Summary
Cephalosporin C zinc salt displays a diverse range of bioactivities. It exhibits high potency as a modulator of Lamin A splicing with an IC50 value of 4.0 nM. As an inhibitor, it targets several enzymes and interactions with varying degrees of effectiveness: Human Jumonji Domain Containing 2E (JMJD2E) at 28183.8 nM, Tyrosyl-DNA Phosphodiesterase (TDP1) at 25118.9 nM, and Bloom's syndrome helicase (BLM) also at 28183.8 nM. The compound inhibits the proliferation of Plasmodium falciparum lines W2 and GB4 with potencies of 10000.0 nM and 5011.9 nM, respectively. For Tau fibril formation, it shows potencies of 7079.5 nM measured by Thioflavin T binding and 7943.3 nM measured by fluorescence polarization. Additionally, Cephalosporin C zinc salt has an IC50 of 12589.3 nM as an inhibitor targeting the Menin-MLL interaction in MLL-related leukemias, and 19952.6 nM for inhibiting the binding or entry of the Marburg Virus into cells. It also inhibits MPP8 Chromodomain interactions with methylated histone tails and Polymerase Iota, both with potencies of 44668.4 nM..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Cephalosporin C zinc salt was a potent inhibitor of SAMHD1 (IC50 : 1.1 ± 0.1 μM), and this inhibition was largely attributable to the presence of zinc. |
| Targets&IC50 | SAMHD1:1.1 μM |
| Molecular Weight | 478.78 |
| Formula | C16H19N3O8SZn |
| Cas No. | 59143-60-1 |
| Smiles | CC(OCC1=C(N2[C@@H]([C@@H](C2=O)NC(CCC[C@H](C([O-])=O)N)=O)SC1)C([O-])=O)=O.[Zn+2] |
| Relative Density. | no data available |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 4.5 mg/mL (9.4 mM), when pH is adjusted to 6 with HCl. Sonication is recommmended.  0.1 M HCl: 5 mg/mL (10.44 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO/0.1 M HCl
0.1 M HCl
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||||||||||||