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> Cd4 (non-polymorphic epitope) Rat Monoclonal Antibody [Clone ID: YTS177.9]

Cd4 (non-polymorphic epitope) Rat Monoclonal Antibody [Clone ID: YTS177.9]

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Cd4 (non-polymorphic epitope) Rat Monoclonal Antibody [Clone ID: YTS177.9]

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SKU
SM019LE
Cd4 (non-polymorphic epitope) rat monoclonal antibody, clone YTS177.9, Low Endotoxin
Size:
500 ug
Conjugation:
Unconjugated
 

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Specifications
Product Data
Clone Name YTS177.9
Application FC
Recommended Dilution Flow Cytometry: Use 10 µl of 1/50-1/200 diluted antibody to label 10e6 cells in 100 µl.
Reactivity Mouse
Antibody Host Rat
Isotype IgG2a
Clonality Monoclonal
Immunogen Mouse spleen cells.
Spleen cells from immunised DA rats were fused with cells of the Y3/Ag1.2.3 rat myeloma cell line.
Specificity SM019LE recognises Murine CD4, a 55kD cell surface antigen expressed by a subset of T lymphocytes.
This Low Endotoxin CD4 antibody is reported to block MHC class II dependant T-cell responses in vitro and in vivo and induces tolerance.
Buffer PBS, pH 7.4 without preservatives.
State: Low Endotoxin
State: Liquid purified IgG fraction.
Concentration lot specific
Purification Protein G Affinity chromatography from tissue culture supernatant
Conjugation Unconjugated
Storage Store the antibody at -20°C.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Shipping Blue Ice
Gene Name CD4 antigen
Database Link
Background CD4 is a single chain transmembrane glycoprotein and belongs to immunoglobulin supergene family. In extracellular region there are 4 immunoglobulin-like domains (1 Ig-like V-type and 3 Ig-like C2-type). Transmembrane region forms 25 aa, cytoplasmic tail consists of 38 aa. Domains 1,2 and 4 are stabilized by disulfide bonds. The intracellular domain of CD4 is associated with p56Lck, a Src-like protein tyrosine kinase. It was described that CD4 segregates into specific detergent-resistant T-cell membrane microdomains.
Extracellular ligands: MHC class II molecules (binds to CDR2-like region in CD4 domain 1); HIV envelope protein gp120 (binds to CDR2-like region in CD4 domain 1); IL-16 (binds to CD4 domain 3), Human seminal plasma glycoprotein gp17 (binds to CD4 domain 1), L-selectin
Intracellular ligands: p56Lck
CD4 is a co-receptor involved in immune response (co-receptor activity in binding to MHC class II molecules) and HIV infection (human immunodeficiency virus; CD4 is primary receptor for HIV-1 surface glycoprotein gp120). CD4 regulates T-cell activation, T/B-cell adhesion, T-cell diferentiation, T-cell selection and signal transduction. Defects in antigen presentation (MHC class II) cause dysfunction of CD4+ T-cells and their almost complete absence in patients blood, tissue and organs (SCID immunodeficiency).
Synonyms T-cell surface antigen T4/Leu-3
Reference Data
Protein Categories ADC Targets, CD Markers, Immune system diseases, Intracellular Proteins, Membrane Proteins
Product Manuals
FAQs
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SDS
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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