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> CD133/PROM1 Protein, Rat, Recombinant (mFc)

CD133/PROM1 Protein, Rat, Recombinant (mFc)

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CD133/PROM1 Protein, Rat, Recombinant (mFc)

(Synonyms: prominin 1) Copy Product Info

Synonyms: prominin 1

Catalog No. TMPY-03690 Copy Product Info
CD133/PROM1 Protein, Rat, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 60 kDa and the accession number is Q7TSL4.
Other Forms of CD133/PROM1 Protein, Rat, Recombinant (mFc):
CD133/PROM1 Protein, Mouse, Recombinant (His & SUMO)
CD133/PROM1 Protein, Rat, Recombinant (His)
For research use only—not for human use. No sales to individuals. Use as intended only.

Product Introduction

Bioactivity
Bioactivity
Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description
CD133/PROM1 Protein, Rat, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 60 kDa and the accession number is Q7TSL4.
Species
Rat
Expression System
HEK293 Cells
TagN-mFc
Accession NumberQ7TSL4
ConstructionA DNA sequence encoding the rat PROM1 (NP_001103607.1) (Asn171-Tyr424) was with the Fc region of mouse IgG1 at the N-terminus. Predicted N terminal: Asp
Protein Purity
> 90 % as determined by SDS-PAGE
Endotoxin< 1.0 EU/μg of the protein as determined by the LAL method.
FormulationLyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
ReconstitutionA Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Synonymsprominin 1
Research Background
CD133, also known as PROM1 and Prominin 1, is a pentaspan transmembrane glycoprotein that belongs to the prominin family. It localizes to membrane protrusions and is often expressed on adult stem cells. CD133 is known to play a role in maintaining stem cell properties by suppressing differentiation. CD133 binds cholesterol in cholesterol-containing plasma membrane microdomains. It is proposed to play a role in apical plasma membrane organization of epithelial cells. CD133 is also involved in regulation of MAPK and Akt signaling pathways. Mutations in PROM1 gene have been shown to result in retinitis pigmentosa and Stargardt disease. PROM1 gene is expressed from at least five alternative promoters that are expressed in a tissue-dependent manner. Expression of this gene is also associated with several types of cancer.
Chemical Properties
Molecular Weight60 kDa (predicted); 67 and 34 kDa (reducing condition, due to glycosylation)
Storage & Solubility Information
ShippingIn general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
StorageIt is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

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Related Tags: CD133/PROM1 Protein, Rat, Recombinant (mFc) chemical structure | CD133/PROM1 Protein, Rat, Recombinant (mFc) molecular weight