General Information
| Short Description | CCK4 Blocking Peptide is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Applications | Immunodepletion/Immunocompetition |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Formulation | Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | |
| Gene ID | |
| Uniprot ID | |
| Immunogen | Purified Protein tyrosine kinase 7 protein was emulsified in complete adjuvant and used to immunize the rabbits. |
Additional Info
| Tissue Specificity | Highly expressed in brain and kidney. |
| Post Translational Modifications | Autophosphorylated on Ser/Thr. Phosphorylated in cytosol under basal conditions and dephosphorylated when membrane-associated. The activity of MAP3K12 can be regulated through its proteasomal degradation. APOE, through a receptor-mediated mechanism, activates MAP3K12 by preventing its proteasomal degradation. |
| Function | Part of a non-canonical MAPK signaling pathway. Activated by APOE, enhances the AP-1-mediated transcription of APP, via a MAP kinase signal transduction pathway composed of MAP2K7 and MAPK1/ERK2 and MAPK3/ERK1. May be an activator of the JNK/SAPK pathway. |
| Peptide Name | Mitogen-Activated Protein Kinase Kinase Kinase 12Dual Leucine Zipper Bearing KinaseDlkLeucine-Zipper Protein KinaseZpkMapk-Upstream KinaseMukMixed Lineage Kinase |
| Cellular Localisation | CytoplasmCell MembraneBehaves Essentially As An Integral Membrane Protein |
| Alternative Peptide Names | Mitogen-Activated Protein Kinase Kinase Kinase 12 proteinDual Leucine Zipper Bearing Kinase proteinDlk proteinLeucine-Zipper Protein Kinase proteinZpk proteinMapk-Upstream Kinase proteinMuk proteinMixed Lineage Kinase proteinMAP3K12 proteinZPK protein |
Information sourced from Uniprot.org