Carboxy pyridostatin trifluoroacetate salt is a G-quadruplex ligand. Carboxy pyridostatin trifluoroacetate salt has a highly molecular specificity to RNA on DNA G4s and reduces ATF-5 protein. Carboxy pyridostatin trifluoroacetate salt reduces cell proliferation and hinders stress granule (SG) formation^[1][2][3].

Carboxy pyridostatin trifluoroacetate salt (1-25 μM; 3 days) reduces the size of adult SVZ-derived neurospheres and the number of cells in neurospheres, and blocks proliferation and neurosphere fusion in adult SVZ-derived neurosphere cultures^[1].
Carboxy pyridostatin trifluoroacetate salt (10 μM; 24 h) hinders stress granule (SG) formation in U2OS cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

• [1]. Goldberg DC, et al. Manipulating Adult Neural Stem and Progenitor Cells with G-Quadruplex Ligands. ACS Chem Neurosci. 2020;11(10):1504-1518.  [Content Brief]

  [2]. Rocca R, et al. Molecular recognition of a carboxy pyridostatin toward G-quadruplex structures: Why does it prefer RNA? Chem Biol Drug Des. 2017 Nov;90(5):919-925.  [Content Brief]

  [3]. Turner M, et al. rG4detector, a novel RNA G-quadruplex predictor, uncovers their impact on stress granule formation. Nucleic Acids Res. 2022 Nov 11;50(20):11426-11441.  [Content Brief]