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Synonyms: Sodium carbenicillin, BRL-2064
| Description | Carbenicillin disodium (BRL-2064) is a broad-spectrum, semi-synthetic penicillin antibiotic with bactericidal and beta-lactamase resistant activity. |
| In vitro | In patients with cystic fibrosis, Carbenicillin (0.1μg/mL) exhibited no hypersensitivity drug reactions as measured by antibody levels. In chrysanthemums and TOBC, Carbenicillin (50 μg/mL) induced phytotoxicity in a concentration-dependent manner. |
| In vivo | Carbenicillin (125 mg/L) effectively suppresses the proliferation of soil bacteria, increases the volume of somatic embryos, and the number of somatic embryos per callus tissue. Within the callus tissue, Carbenicillin at concentrations of 250 mg/L to 500 mg/L can enhance the fresh weight of the tissue. At a higher concentration of 1 g/L, Carbenicillin reduces the germination frequency of leaf disc explants. Additionally, in vitro exposure of patients' isolated leukocytes to Carbenicillin (0.1 g/ml) does not result in histamine release. |
| Synonyms | Sodium carbenicillin, BRL-2064 |
| Molecular Weight | 422.36 |
| Formula | C17H16N2Na2O6S |
| Cas No. | 4800-94-6 |
| Smiles | [Na+].[C@H]1(C(=O)N2[C@@H]1SC([C@@H]2C(=O)[O-])(C)C)NC(=O)C(C(=O)[O-])c1ccccc1.[Na+] |
| Relative Density. | no data available |
| Storage | The compound is unstable in solution. Please use soon Powder: -20°C for 3 years Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: < 1 mg/mL (insoluble), The compound is unstable in solution, please use soon.  Ethanol: < 1 mg/mL (insoluble or slightly soluble), The compound is unstable in solution, please use soon. DMSO: 62.5 mg/mL (147.98 mM), Sonication is recommended. The compound is unstable in solution, please use soon. | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.74 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||||||||||||||||||||||
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
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