BRLF1 Antibody
Referencia OABF01444
embalaje : 100ul
Marca : Aviva Systems Biology
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HMGB1 Recombinant Antibody [1A1] (OACA12543)
| Datasheets/Manuals | Printable datasheet for HMGB1 Recombinant Antibody [1A1] (OACA12543) |
|---|
| Predicted Species Reactivity | Human |
|---|---|
| Product Format | Liquid |
| Clonality | Recombinant Monoclonal |
| Conjugation | Unconjugated |
| Application | Enzyme-linked immunosorbent assay, Immunohistochemistry, Western blot |
| Reconstitution and Storage | -20°C or -80°C |
| Immunogen | A synthesized peptide derived from human HMGB1 |
| Purification | Affinity Purified |
| Gene Symbol | HMGB1 |
|---|---|
| Gene Full Name | high mobility group box 1 |
| Alias Symbols | Amphoterin;High mobility group protein 1;high mobility group protein B1;high-mobility group (nonhistone chromosomal) protein 1;HMG1;HMG-1;HMG3;SBP-1;Sulfoglucuronyl carbohydrate binding protein. |
| NCBI Gene Id | 3146 |
| Protein Name | High mobility group protein B1 |
| Description of Target | Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as danger associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury (PubMed:27362237). Released to the extracellular environment can bind DNA, nucleosomes, IL-1 beta, CXCL12, AGER isoform 2/sRAGE, lipopolysaccharide (LPS) and lipoteichoic acid (LTA), and activates cells through engagement of multiple surface receptors. In the extracellular compartment fully reduced HMGB1 (released by necrosis) acts as a chemokine, disulfide HMGB1 (actively secreted) as a cytokine, and sulfonyl HMGB1 (released from apoptotic cells) promotes immunological tolerance (PubMed:23519706, PubMed:23446148, PubMed:23994764, PubMed:25048472). Has proangiogdenic activity (By similarity). May be involved in platelet activation (By similarity). Binds to phosphatidylserine and phosphatidylethanolamide (By similarity). Bound to RAGE mediates signaling for neuronal outgrowth (By similarity). May play a role in accumulation of expanded polyglutamine (polyQ) proteins such as huntingtin (HTT) or TBP (PubMed:23303669, PubMed:25549101). |
| Uniprot ID | P09429 |