| Short Description : | Mouse monoclonal anti-NF-kappa-B inhibitor alpha (N-Term) for use in WB in Human, Mouse, Rat, Pig and Sheep samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB |
| Host: | Mouse |
| Reactivity: | Human/Mouse/Rat/Pig/Sheep |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:1000-1:2000 |
| Formulation: | Liquid in 0.1M Tris-Glycine (pH7.4, 150 mM NaCl) , 0.2% Sodium Azide and 50% Glycerol. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
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| Immunogen: | Purified recombinant human I Kappa B-Alpha (N-terminus) protein fragments expressed in E.coli. |
| Immunogen Region: | N-Term |
| Specificity: | I Kappa B-Alpha Monoclonal Antibody detects endogenous levels of I Kappa B-Alpha protein. |
| Function | Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL (RELA/p65 and NFKB1/p50) dimers in the cytoplasm by masking their nuclear localization signals. On cellular stimulation by immune and pro-inflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription. |
| Protein Name | Nf-Kappa-B Inhibitor AlphaI-Kappa-B-AlphaIkb-AlphaIkappabalphaMajor Histocompatibility Complex Enhancer-Binding Protein Mad3 |
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| Cellular Localisation | CytoplasmNucleusShuttles Between The Nucleus And The Cytoplasm By A Nuclear Localization Signal (Nls) And A Crm1-Dependent Nuclear Export |
| Alternative Antibody Names | Anti-Nf-Kappa-B Inhibitor Alpha antibodyAnti-I-Kappa-B-Alpha antibodyAnti-Ikb-Alpha antibodyAnti-Ikappabalpha antibodyAnti-Major Histocompatibility Complex Enhancer-Binding Protein Mad3 antibodyAnti-NFKBIA antibodyAnti-IKBA antibodyAnti-MAD3 antibodyAnti-NFKBI antibody |
Information sourced from Uniprot.org