| Short Description : | Rabbit monoclonal IgD (Full Length) antibody for use in IHC-P in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | IHC-P |
| Host: | Rabbit |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | ZR156 |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Purification: | Affinity purified |
| Dilution Range: | 1:100-200 |
| Formulation: | Tris-HCI buffer containing stabilizing protein (BSA) and <0.1% ProClin |
| Storage Instruction: | Store at 2‐8°C for up to 24 months. Predilute: Ready to use, no reconstitution necessary. Concentrate: Use dilution range and appropriate lab‐standardized diluent. Stability after dilution: 7 days at 24°C, 3 months at 2‐8°C, 6months at ‐20°C. |
| Immunogen: | Full-length human IGHD protein |
| Immunogen Region: | Full Length |
| Specificity: | Positive Control: Lymph node |
| Background | Zeta IgD Antibody. Zeta s rabbit polyclonal antibody recognizes IgD, a protein that plays a biological role as a transmembrane receptor molecule and is co-expressed with IgM on the surface of mature/naive B cells. In particular, it is found on spleen B cell surfaces. IgD is an immunoglobulin which are four-chain, Y-shaped, monomeric structures comprised of two identical heavy chains and two identical light chains held together through interchain disulfide bonds. The chains form two domains, the Fab (antigen binding) fragment, and the Fc (constant) fragment. Immunoglobulin D (IgD) is a monomer with Delta heavy chains and either Kappa or Lambda light chains. IgD plays a biological role as a transmembrane receptor molecule, co-expressed with IgM on the surface of mature/naive B cells. In particular, IgD is found on spleen B cell surfaces. Compared to IgM, IgD exists in much lower numbers and is not expressed in immature B cells. IgD surface expression on B cells is regulated in part by IL-27. In mice, the inhibition of the IgD isotype does not cause a significant change to the immune system. Zeta s antibody to IgD is helpful when identifying leukemia, plasmacytomas and B-cell lineage lymphomas. In tonsil and lymph node, immunohistochemical staining for IgD is used to highlight tonsil and nodal architecture. Zeta Corporation is a leader in recombinant monoclonal IVD antibodies for immunohistochemistry (IHC) offering 400+ tumor and tissue specific relevant products developed by a pathologist for pathologists. Visit Precision Recombinant Antibodies – IVD Antibodies – About Zeta Corporation (zeta-corp.com) to learn more about Zeta Corporation. |
Information sourced from Uniprot.org