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> Anti-CDT1 Antibody (4Q313)

Anti-CDT1 Antibody (4Q313)

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Anti-CDT1 Antibody (4Q313)

(Synonyms: RIS2, RIS 2, Retroviral integration site2, Retroviral integration site1, Retroviral integration site 2, Retroviral integration site 1, DUP, Double parked homolog, Double parked Drosophila homolog of, Double parked, DNA replication factor Cdt1, DNA replication factor, Chromatin licensing and DNA replication factor 1, CDT1_HUMAN, cdt1, CDT 1) Copy Product Info

Synonyms: RIS2, RIS 2, Retroviral integration site2, Retroviral integration site1, Retroviral integration site 2, Retroviral integration site 1, DUP, Double parked homolog, Double parked Drosophila homolog of, Double parked, DNA replication factor Cdt1, DNA replication factor, Chromatin licensing and DNA replication factor 1, CDT1_HUMAN, cdt1, CDT 1

Catalog No. TMAC-00805 Copy Product Info
Anti-CDT1 Antibody (4Q313) is a Rabbit antibody targeting CDT1. Anti-CDT1 Antibody (4Q313) can be used in IHC,IP,WB.
For research use only—not for human use. No sales to individuals. Use as intended only.

Product Introduction

Bioactivity
Description
Anti-CDT1 Antibody (4Q313) is a Rabbit antibody targeting CDT1. Anti-CDT1 Antibody (4Q313) can be used in IHC,IP,WB.
SynonymsRIS2, RIS 2, Retroviral integration site2, Retroviral integration site1, Retroviral integration site 2, Retroviral integration site 1, DUP, Double parked homolog, Double parked Drosophila homolog of, Double parked, DNA replication factor Cdt1, DNA replication factor, Chromatin licensing and DNA replication factor 1, CDT1_HUMAN, cdt1, CDT 1
Ig Type
IgG
Clone
4Q313
Reactivity
Human
Verified Activity
1. Western blot analysis of CDT1 on Hela cell using anti-CDT1 antibody at 1/1,000 dilution.
2. Immunohistochemical analysis of paraffin-embedded human skin tissue using anti-CDT1 antibody. Counter stained with hematoxylin.
Anti-CDT1 Antibody (4Q313),Anti-CDT1 Antibody (4Q313)
Application
IHC
IP
WB
Recommended Dose
WB: 1:500-1000; IHC: 1:25-50
Antibody Type
Monoclonal
Host SpeciesRabbit
ConstructionRecombinant Antibody
PurificationProA affinity purified
AppearanceLiquid
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Research BackgroundHuman Cdt1 is a nuclear localizing replication initiation factor that is expressed only during the G1 and S phases of the cell cycle. In conjunction with Cdc18, Cdt1 is required to load the MCM protein Cdc21 onto chromatin at the end of mitosis which is necessary to initiate DNA replication. After S-phase onset, Cdt1 protein levels decrease and are barely detectable in cells in early S-phase or G2. However, Cdt1 mRNA is expressed in S-phase-arrested cells, and its levels do not change dramatically during the cell cycle, suggesting that proteolytic degradation rather than transcriptional controls ensure proper accumulation of Cdt1. Cdt1 can associate with the DNA replication inhibitor geminin, which is present in the S and G2 phases of the cell cycle. Inhibition of DNA replication by geminin in cell-free DNA replication extracts can be reversed by the addition of excess Cdt1. Geminin may be responsible for preventing inappropriate origin firing by targeting Cdt1.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Protein
Uniprot ID
Q9H211
Chemical Properties
Molecular WeightTheoretical: 60 kDa.
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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