| Short Description : | Mouse monoclonal anti-CD45RA for use in FC in Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | FC |
| Host: | Mouse |
| Reactivity: | Rat |
| Note: | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | OX-33 |
| Isotype: | IgG1k |
| Conjugation: | APC |
| Concentration: | 5 Mu L/Test |
| Purification: | Affinity purified |
| Formulation: | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant. |
| Storage Instruction: | Store between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product. |
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| Tissue Specificity | Isoform 1 and isoform 2 are found in thymocyte and lymph node. Isoform 4 and isoform 3 are found in the lymph nod. |
| Post Translational Modifications | Heavily N- and O-glycosylated. The cytoplasmic domain contains potential phosphorylation sites. |
| Function | Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity. Interacts with CLEC10A at antigen presenting cell-T cell contact.CLEC10A on immature dendritic cells recognizes Tn antigen-carrying PTPRC/CD45 receptor on effector T cells and modulates T cell activation threshold to limit autoreactivity. |
| Protein Name | Receptor-Type Tyrosine-Protein Phosphatase CLeukocyte Common AntigenL-CaT200Cd Antigen Cd45 |
| Database Links | |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinMembrane RaftSynapseColocalized With Dpp4 In Membrane Rafts |
| Alternative Antibody Names | Anti-Receptor-Type Tyrosine-Protein Phosphatase C antibodyAnti-Leukocyte Common Antigen antibodyAnti-L-Ca antibodyAnti-T200 antibodyAnti-Cd Antigen Cd45 antibodyAnti-Ptprc antibody |
Information sourced from Uniprot.org