Anti-CD11c Monoclonal Antibody (Clone:BU15)-PE Conjugated
Figure 1: Surface staining of human peripheral blood cells with anti-CD11c (BU15) PE.
| Amount : | 100 tests |
| Isotype : | Mouse IgG1 |
| Storage condition : | Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. |
CD11c (p150, alphaX integrin subunit) forms complex with CD18 (beta2 integrin subunit) and is expressed mainly on tissue macrophages and dendritic cells. CD11c binds to complement fragment iC3b, fibrinogen, VCAM-1 and ICAM-2 or e.g. CD90. Like other beta2 integrins, CD11c/CD18 plays roles in cell migration and phagocytosis. Moreover, interaction of CD11c/CD18 with plasminogen regulates plasmin activities, and interaction with heparin counteracts binding of iC3b.
| Subcellular location: | Membrane |
| Tissue Specificity: | Predominantly expressed in monocytes and granulocytes. |
| BioGrid: | 109893. 1 interactions. |
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