Amyloid beta-peptide(25-35) [131602-53-4]

Biological Activity

Amyloid beta-peptide(25-35) is the fragment Aβ(25-35) of the Alzheimer's amyloid β-peptide, has shown neurotoxic activities in cultured cells. Amyloid beta-peptide(25-35) is also investigated in gel state for the first time. Comparative studies are also carried out using vibrational absorption and ECD. Amyloid beta-peptide(25-35) induces apoptotic effects on isolated brain mitochondria and the redox state of methionine-35.

In vivo, rats injected with Aβ25–35 peptide intracerebroventricularly and compound Danshen (CDS) are subsequently administered once daily for 23 days. The Alzheimer' s disease (AD) model group present with spatial learning and memory impairments. CDS and donepezil administration significantly ameliorate the Aβ25–35 peptide-induced memory impairment in both Morris water maze (P < 0.05) and passive avoidance task (P < 0.01) compared to the AD model group.

Chemical Information

Molecular Weight	1060.27
Formula	C45H81N13O14S
CAS Number	131602-53-4
Solubility (25°C)	DMSO: ≥ 60 mg/mL
Storage	Powder          -20°C   3 years ;  4°C   2 years In solvent       -80°C   6 months ;  -20°C   1 month

References

[1] Liu M, et al. BMC Complement Altern Med. Cognitive improvement of compound danshen in an Aβ25-35 peptide-induced rat model of Alzheimer's disease.

[2] Clementi ME, et al. FEBS Lett. Abeta(31-35) and Abeta(25-35) fragments of amyloid beta-protein induce cellular death through apoptotic signals: Role of the redox state of methionine-35.

[3] DUrsi AM, et al. J Med Chem. Solution structure of amyloid beta-peptide (25-35) in different media.