Amoxicillin Sodium [34642-77-8]

Biological Activity

Amoxicillin sodium (Amox) is a moderate- spectrum, bacteriolytic, β-lactam antibiotic. Amoxicillin sodium (Amox) is used to treat bacterial infections caused by susceptible microorganisms. Amoxicillin sodium (Amox) is usually the compound of choice within the class because it is better absorbed, following oral administration, than other β-lactam antibiotics. Amoxicillin sodium (Amox) is susceptible to degradation by β-lactamase-producing bacteria, which are resistant to a broad spectrum of β-lactam antibiotics, such as penicillin. For this reason, it is often combined with clavulanic acid. Amoxicillin sodium (Amox) acts by inhibiting the synthesis of bacterial cell walls. Amoxicillin sodium (Amox) inhibits cross-linkage between the linear peptidoglycan polymer chains that make up a major component of the cell walls of both Gram-positive and Gram-negative bacteria.

Chemical Information

Molecular Weight	387.39
Formula	C16H18N3O5S.Na
CAS Number	34642-77-8
Solubility (25°C)	Water 80 mg/mL DMSO 80 mg/mL
Storage	Powder          -20°C   3 years ;  4°C   2 years In solvent       -80°C   6 months ;  -20°C   1 month

References

[1] Trusha J Purohit, et al. Rectal bioavailability of amoxicillin sodium in rabbits: Effects of suppository base and drug dose

[2] Chongjun Zhang, et al. Could co-substrate sodium acetate simultaneously promote Chlorella to degrade amoxicillin and produce bioresources?

[3] Jrgen Slots. Primer on etiology and treatment of progressive/severe periodontitis: A systemic health perspective

[4] A Huttner, et al. Oral amoxicillin and amoxicillin-clavulanic acid: properties, indications and usage

[5] Bo-Hao Tang, et al. Population Pharmacokinetics and Dosing Optimization of Amoxicillin in Neonates and Young Infants