Prazosin [19216-56-9]
Cat# HY-B0193-10mg
Size : 10mg
Brand : MedChemExpress
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- Antibody-drug Conjugate/ADC Related
- Apoptosis
- Autophagy
- Cell Cycle/DNA Damage
- Cytoskeleton
- Epigenetics
- GPCR/G Protein
- Immunology/Inflammation
- JAK/STAT Signaling
- MAPK/ERK Pathway
- Membrane Transporter/Ion Channel
- Metabolic Enzyme/Protease
- Neuronal Signaling
- NF-κB
- PI3K/Akt/mTOR
- PROTAC
- Protein Tyrosine Kinase/RTK
- Stem Cell/Wnt
- TGF-beta/Smad
- Vitamin D Related/Nuclear Receptor
- Others
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
- Protocol 1
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (13.04 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Dosage
mg/kgAnimal weight
(per animal)
Dosing volume
(per animal)
Number of animals
*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
-
[1]. Day HE, et al. Distribution of alpha 1a-, alpha 1b- and alpha 1d-adrenergic receptor mRNA in the rat brain and spinal cord. J Chem Neuroanat. 1997 Jul;13(2):115-39. [Content Brief]
[2]. Yu CX, et al. Selective MT(2) melatonin receptor antagonist blocks melatonin-induced antinociception in rats. Neurosci Lett. 2000 Mar 24;282(3):161-4. [Content Brief]
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[1]. Day HE, et al. Distribution of alpha 1a-, alpha 1b- and alpha 1d-adrenergic receptor mRNA in the rat brain and spinal cord. J Chem Neuroanat. 1997 Jul;13(2):115-39.
[2]. Yu CX, et al. Selective MT(2) melatonin receptor antagonist blocks melatonin-induced antinociception in rats. Neurosci Lett. 2000 Mar 24;282(3):161-4.
* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
---|
DMSO | 1 mM | 2.6082 mL | 13.0412 mL | 26.0824 mL | 65.2061 mL |
5 mM | 0.5216 mL | 2.6082 mL | 5.2165 mL | 13.0412 mL | |
10 mM | 0.2608 mL | 1.3041 mL | 2.6082 mL | 6.5206 mL | |
15 mM | 0.1739 mL | 0.8694 mL | 1.7388 mL | 4.3471 mL | |
20 mM | 0.1304 mL | 0.6521 mL | 1.3041 mL | 3.2603 mL | |
25 mM | 0.1043 mL | 0.5216 mL | 1.0433 mL | 2.6082 mL | |
30 mM | 0.0869 mL | 0.4347 mL | 0.8694 mL | 2.1735 mL | |
40 mM | 0.0652 mL | 0.3260 mL | 0.6521 mL | 1.6302 mL | |
50 mM | 0.0522 mL | 0.2608 mL | 0.5216 mL | 1.3041 mL | |
60 mM | 0.0435 mL | 0.2174 mL | 0.4347 mL | 1.0868 mL | |
80 mM | 0.0326 mL | 0.1630 mL | 0.3260 mL | 0.8151 mL | |
100 mM | 0.0261 mL | 0.1304 mL | 0.2608 mL | 0.6521 mL |
- GPCR/G Protein Neuronal Signaling
- Adrenergic Receptor
-
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.
Keywords:
Prazosin19216-56-9Adrenergic ReceptorBeta ReceptorInhibitorinhibitorinhibit
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- Product Name:
- Prazosin
- Cat. No.:
- HY-B0193
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