Naproxen (sodium) [26159-34-2]
Cat# HY-15030A-5g
Size : 5g
Brand : MedChemExpress
Please arrange your schedule properly.
- Antibody-drug Conjugate/ADC Related
- Apoptosis
- Autophagy
- Cell Cycle/DNA Damage
- Cytoskeleton
- Epigenetics
- GPCR/G Protein
- Immunology/Inflammation
- JAK/STAT Signaling
- MAPK/ERK Pathway
- Membrane Transporter/Ion Channel
- Metabolic Enzyme/Protease
- Neuronal Signaling
- NF-κB
- PI3K/Akt/mTOR
- PROTAC
- Protein Tyrosine Kinase/RTK
- Stem Cell/Wnt
- TGF-beta/Smad
- Vitamin D Related/Nuclear Receptor
- Others
Naproxen sodium
- Cat. No.: HY-15030A Purity: 99.87%
- COA Handling Instructions
Naproxen sodium is a COX-1 and COX-2 inhibitor with IC50s of 8.72 and 5.15 μM, respectively in cell assay.
For research use only. We do not sell to patients.
Naproxen sodium Chemical Structure
CAS No. : 26159-34-2
Size | Stock | Quantity | |
---|---|---|---|
Free Sample (0.1 - 0.5 mg) | Apply Now | ||
Solid + Solvent | |||
10 mM * 1 mL in DMSO ready for reconstitution | USD 55 | In-stock | |
Solution | |||
10 mM * 1 mL in DMSO | USD 55 | In-stock | |
Solid | |||
500 mg | USD 50 | In-stock | |
5 g | USD 60 | In-stock | |
10 g | USD 96 | In-stock | |
50 g | Get quote |
* Please select Quantity before adding items.
This product is a controlled substance and not for sale in your territory.
Customer Review
Based on 2 publication(s) in Google Scholar
Other Forms of Naproxen sodium:
- (±)-Naproxen In-stock
- Naproxen In-stock
- Naproxen etemesil In-stock
2 Publications Citing Use of MCE Naproxen sodium
View All COX Isoform Specific Products:
Biological Activity
Protocol
Purity & Documentation
References
Customer Review
Description | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IC50 & Target[1] |
| ||||||||||||
In Vitro | Naproxen etemesil is a lipophilic, non-acidic, inactive prodrug of naproxen that is hydrolysed to pharmacologically active Naproxen once absorbed. Naproxen is a well known nonsteroidal anti-inflammatory drug. Naproxen is approximately equipotent inhibitor of COX-1 and COX-2 in intact cells with IC50s of 2.2 μg/mL and 1.3 μg/mL, respectively[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. | ||||||||||||
In Vivo | Naproxen exerts an anti-inflammatory and antifibrotic effect in mouse model of bleomycin-induced lung fibrosis. Naproxen also downregulates TGF-β levels and Smad3/4 complex formation[2]. Naproxen is shown to inhibit the time-courses of pain, fever and PGE2 with similar potencies (IC50=27, 40, 13 μM)[3]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. | ||||||||||||
Clinical Trial | | ||||||||||||
Molecular Weight | 252.24 | ||||||||||||
Formula | C14H13NaO3 | ||||||||||||
CAS No. | |||||||||||||
Appearance | Solid | ||||||||||||
Color | White to off-white | ||||||||||||
SMILES | C[C@H](C(O[Na])=O)C1=CC2=CC=C(OC)C=C2C=C1 | ||||||||||||
Shipping | Room temperature in continental US; may vary elsewhere. | ||||||||||||
Storage | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) | ||||||||||||
Solvent & Solubility | In Vitro: H2O : 75 mg/mL (297.34 mM; Need ultrasonic and warming) DMSO : 5 mg/mL (19.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) Preparing Stock Solutions
View the Complete Stock Solution Preparation Table * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles. * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo: Select the appropriate dissolution method based on your experimental animal and administration route. For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
In Vivo Dissolution Calculator Please enter the basic information of animal experiments: Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments. Calculation results: Working solution concentration: mg/mL This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details. The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE). | ||||||||||||
Purity & Documentation | Purity: 99.87% | ||||||||||||
References |
|
Complete Stock Solution Preparation Table
* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
---|
DMSO / H2O | 1 mM | 3.9645 mL | 19.8224 mL | 39.6448 mL | 99.1120 mL |
5 mM | 0.7929 mL | 3.9645 mL | 7.9290 mL | 19.8224 mL | |
10 mM | 0.3964 mL | 1.9822 mL | 3.9645 mL | 9.9112 mL | |
15 mM | 0.2643 mL | 1.3215 mL | 2.6430 mL | 6.6075 mL | |
H2O | 20 mM | 0.1982 mL | 0.9911 mL | 1.9822 mL | 4.9556 mL |
25 mM | 0.1586 mL | 0.7929 mL | 1.5858 mL | 3.9645 mL | |
30 mM | 0.1321 mL | 0.6607 mL | 1.3215 mL | 3.3037 mL | |
40 mM | 0.0991 mL | 0.4956 mL | 0.9911 mL | 2.4778 mL | |
50 mM | 0.0793 mL | 0.3964 mL | 0.7929 mL | 1.9822 mL | |
60 mM | 0.0661 mL | 0.3304 mL | 0.6607 mL | 1.6519 mL | |
80 mM | 0.0496 mL | 0.2478 mL | 0.4956 mL | 1.2389 mL | |
100 mM | 0.0396 mL | 0.1982 mL | 0.3964 mL | 0.9911 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Naproxen sodium Related Classifications
-
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.
Your Recently Viewed Products:
Inquiry Online
Your information is safe with us. * Required Fields.
Bulk Inquiry
Inquiry Information
- Product Name:
- Naproxen sodium
- Cat. No.:
- HY-15030A
- Quantity:
- MCE Japan Authorized Agent: