Methylprednisolone succinate (sodium) [2375-03-3]
Cat# HY-B1060-10mg
Size : 10mg
Brand : MedChemExpress
Methylprednisolone succinate (Methylprednisolone hydrogen succinate) sodium, a glucocorticoid, is a immunosuppressive agent with anti-inflammatory effects.
For research use only. We do not sell to patients.
Methylprednisolone succinate sodium Chemical Structure
CAS No. : 2375-03-3
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This product is a controlled substance and not for sale in your territory.
Biological Activity
Purity & Documentation
References
Customer Review
Methylprednisolone succinate (Methylprednisolone hydrogen succinate) sodium, a glucocorticoid, is a immunosuppressive agent with anti-inflammatory effects. | ||||||||||||||||
In Vitro | Methylprednisolone succinate sodium (1-400 μg; 2 days) inhibits cell growth of human glioblastomas in a dose-dependent manner. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. | |||||||||||||||
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In Vivo | Administration of Methylprednisolone succinate sodium post- intracranial haemorrhage (ICH) significantly reduces permeability of the blood-brain barrier (BBB) and brain oedema and upregulated expression of ZO-1 and Occludin. Methylprednisolone succinate sodium inhibits inflammatory responses, including reducing proinflammatory cytokines (IL-1β, TNF-α), suppressing infiltration of neutrophils and activation of microglia. In addition, Methylprednisolone succinate sodium reduces neuronal apoptosis through increasing Bcl-2 expression and reducing Bax expression. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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496.53 | ||||||||||||||||
C26H33NaO8 | ||||||||||||||||
2375-03-3 | ||||||||||||||||
Solid | ||||||||||||||||
White to off-white | ||||||||||||||||
C[C@@]12[C@](C(COC(CCC(O[Na])=O)=O)=O)(O)CC[C@@]1(11)[C@]3(11)C[C@H](C)C4=CC(C=C[C@]4(C)[C@@]3(11)[C@@H](O)C2)=O | ||||||||||||||||
Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) | ||||||||||||||||
In Vitro: H2O : 50 mg/mL (100.70 mM; Need ultrasonic) DMSO : ≥ 25 mg/mL (50.35 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) *"≥" means soluble, but saturation unknown. Preparing Stock Solutions
View the Complete Stock Solution Preparation Table * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles. * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo: Select the appropriate dissolution method based on your experimental animal and administration route. For the following dissolution methods, please ensure to first prepare a clear stock solution using an and then sequentially add co-solvents:
In Vivo Dissolution Calculator Please enter the basic information of animal experiments: Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments. Calculation results: Working solution concentration: mg/mL This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details. The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE). | ||||||||||||||||
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[1]. Cheng S, Gao W, Xu X, et al. Methylprednisolone sodium succinate reduces BBB disruption and inflammation in a model mouse of intracranial haemorrhage. Brain Res Bull. 2016;127:226-233.
[2]. J Mealey Jr, et al. Effects of dexamethasone and methylprednisolone on cell cultures of human glioblastomas. J Neurosurg. 1971 Mar;34(3):324-34.
* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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DMSO / H2O | 1 mM | 2.0140 mL | 10.0699 mL | 20.1398 mL | 50.3494 mL |
5 mM | 0.4028 mL | 2.0140 mL | 4.0280 mL | 10.0699 mL | |
10 mM | 0.2014 mL | 1.0070 mL | 2.0140 mL | 5.0349 mL | |
15 mM | 0.1343 mL | 0.6713 mL | 1.3427 mL | 3.3566 mL | |
20 mM | 0.1007 mL | 0.5035 mL | 1.0070 mL | 2.5175 mL | |
25 mM | 0.0806 mL | 0.4028 mL | 0.8056 mL | 2.0140 mL | |
30 mM | 0.0671 mL | 0.3357 mL | 0.6713 mL | 1.6783 mL | |
40 mM | 0.0503 mL | 0.2517 mL | 0.5035 mL | 1.2587 mL | |
50 mM | 0.0403 mL | 0.2014 mL | 0.4028 mL | 1.0070 mL | |
H2O | 60 mM | 0.0336 mL | 0.1678 mL | 0.3357 mL | 0.8392 mL |
80 mM | 0.0252 mL | 0.1259 mL | 0.2517 mL | 0.6294 mL | |
100 mM | 0.0201 mL | 0.1007 mL | 0.2014 mL | 0.5035 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
- Immunology/Inflammation Vitamin D Related/Nuclear Receptor
- Glucocorticoid Receptor
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Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.
Keywords:
Methylprednisolone succinate2375-03-3Methylprednisolone hydrogen succinateGlucocorticoid Receptorimmunosuppressive agentglucocorticoidBcl-2 expressionBaxInhibitorinhibitorinhibit
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