Isotretinoin
Cat# M5715-100mg
Size : 100mg
Brand : AbMole Bioscience
Synonym:
13-cis-Retinoic acid
Quality Control & Documentation
Biological Activity
Isotretinoin(13-cis-Retinoic acid) is a medication used for the treatment of severe acne. It was first developed to be used as a chemotherapy medication for the treatment of brain cancer, pancreatic cancer and more.*The compound is unstable in solutions, freshly prepared is recommended
Chemical Information
Molecular Weight | 300.44 |
Formula | C20H28O2 |
CAS Number | 4759-48-2 |
Solubility (25°C) | 10 mM in DMSO |
Storage | -20°C, protect from light, sealed |
Conversion of different model animals based on BSA (PMID: 27057123)
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
References
[1] Rademaker M, et al. Australas J Dermatol. Isotretinoin: dose, duration and relapse. What does 30 years of usage tell us?