Dapagliflozin ((2S)-1,2-propanediol, hydrate)

Cat# M5551-5mg

Size : 5mg

Brand : AbMole Bioscience

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Dapagliflozin ((2S)-1,2-propanediol, hydrate) Structure
Synonym:

BMS-512148 (2S)-1,2-propanediol, hydrate


Quality Control & Documentation
Biological Activity

Dapagliflozin ((2S)-1,2-propanediol, hydrate) is the S-enantiomer of Dapagliflozin 1,2-propanediol, hydrate.

Chemical Information
Molecular Weight 502.98
Formula C24H35ClO9
CAS Number 960404-48-2
Solubility (25°C) 10 mM in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Ghosh RK, et al. J Clin Pharmacol. SGLT2 inhibitors: a new emerging therapeutic class in the treatment of type 2 diabetes mellitus.