Colchicine ((-)-Colchicine)

Cat# C7507-25g

Size : 25g

Brand : US Biological

Contact local distributor :


Phone : +1 850 650 7790


Grade
Reagent Grade

Shipping Temp
RT

Storage Temp
4°C

N-[(7S)-5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzoamheptalen-7-yl]acetamide; (-)-Colchicine; Colchineos; Colchisol; Colcin; Colsaloid; Condylon; NSC 757
Anti-cancer compound. Microtubule assembly inhibitor. Depolymerizes microtubules and limits microtubule formation (inactivates spindle fibre formation). Inhibits mitosis during cell division at metaphase by inhibiting spindle formation. Anti-inflammatory compound. Suppresses monosodium urate crystal-induced NLRP3/NALP3 inflammasome-driven caspase-1 activation, IL-1beta processing and release, and L-selectin expression on neutrophils at micromolar concentrations. Blocks the release of a crystal-derived chemotactic factor from neutrophil lysosomes, blocks neutrophil adhesion to, and inhibits monosodium urate crystal-induced production of superoxide anions from neutrophils at nanomolar concentrations. Drug used in treatment of gout, familial Mediterranean fever, pericarditis and Behect's disease. Investigated for its anti-cancer activity. It has a narrow therapeutic index with no clear-cut distinction between nontoxic, toxic and lethal doses, causing substantial confusion among clinicians. Apoptosis inducer in a variety of normal and tumor cell lines.

Synonyms:
(-)-Colchicine; NSC 757; EINECS 200-598-5, N-​[(7S)-​1,​2,​3,​10-​ tetramethoxy-​9-​oxo-​5,​6,​7,​9-​tetrahydrobenzo​am​heptalen-​ 7-​yl]​acetamide

CAS Number:
64-86-8

Source:
Colchicum autumnale

Molecular Weight:
399.4

Molecular Formula:
C22H25NO6

Purity (HPLC):
Content of Colchicine: 94-101% (HPLC)
Chromatographic Purity: ≥95% (HPLC)

Appearance:
Pale yellow to green crystalline powder

Melting Point:
155-157°C

Optical Rotation:
amD20 = -240 to -250º (C=1 in EtOH)

Water (KF):
≤2%

E. coli, Salmonella, S. aureus:
Negative

Yeast and Mold:
≤100cfu/g

Microbial Count:
≤1000cfu/g (TPC)

Related Substances:
Total Impurity: ≤5%

Residual Solvents:
Limit of Colchicine: Complies
Limit of Ethylacetate: ≤8%
Chloroform: ≤100ppm
Methylene chloride: ≤ 600ppm
Methanol: ≤ 3000ppm
Hexane: ≤290 ppm

Solubility:
100% ethanol (>100mg/ml), DMSO (>100mg/ml), water or DMF

Storage and Stability:
Store at 4°C. Caution: Light-sensitive. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


Toxicity and Hazards
All products should be handled by qualified personnel only, trained in laboratory procedures.