Hydroxychloroquine (sulfate) [747-36-4]
Cat# HY-B1370-50mg
Size : 50mg
Brand : MedChemExpress
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Hydroxychloroquine sulfate (Synonyms: HCQ sulfate)
- Cat. No.: HY-B1370 Purity: 99.90%
- COA Handling Instructions
Hydroxychloroquine sulfate (HCQ sulfate) is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine sulfate is efficiently inhibits SARS-CoV-2 infection in vitro.
For research use only. We do not sell to patients.
Hydroxychloroquine sulfate Chemical Structure
CAS No. : 747-36-4
Size | Price | Stock | Quantity |
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Solid + Solvent | |||
10 mM * 1 mL
in Water
ready for reconstitution
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USD 66 | In-stock | |
Solution | |||
10 mM * 1 mL in Water | USD 66 | In-stock | |
Solid | |||
50 mg | USD 60 | In-stock | |
100 mg | USD 90 | In-stock | |
200 mg | USD 135 | In-stock | |
500 mg | Get quote | ||
1 g | Get quote |
* Please select Quantity before adding items.
This product is a controlled substance and not for sale in your territory.
Customer Review
Based on 49 publication(s) in Google Scholar
Other Forms of Hydroxychloroquine sulfate:
- Hydroxychloroquine In-stock
- (S)-Hydroxychloroquine Get quote
- (R)-Hydroxychloroquine Get quote
- Hydroxychloroquine sulfate (Standard) Get quote
- Hydroxychloroquine-d4 sulfate Get quote
49 Publications Citing Use of MCE Hydroxychloroquine sulfate
- •Nat Biotechnol. 2022 Dec;40(12):1834-1844. [Abstract]
- •Cell Discov. 2020 Mar 18;6:16. [Abstract]
- •Nat Biomed Eng. 2021 Nov 8. [Abstract]
- •Nat Commun. 2022 Jun 14;13(1):3419. [Abstract]
- •Nat Commun. 2021 Aug 16;12(1):4964. [Abstract]
- •Autophagy. 2022 Oct 27. [Abstract]
- •Autophagy. 2022 Aug 29. [Abstract]
- •Arthritis Rheumatol. 2022 Sep 3. [Abstract]
- •Autophagy. 2022 Jan 6;1-20. [Abstract]
- •Autophagy. 2021 Sep 15;1-19. [Abstract]
- •Acta Pharm Sin B. 2021 Dec;11(12):3966-3982. [Abstract]
- •Nucleic Acids Res. 2021 Jan 8;49(D1):D1113-D1121. [Abstract]
- •Theranostics. 2020 Apr 27;10(13):5829-5844. [Abstract]
- •J Control Release. 2020 Jan 28;320:304-313. [Abstract]
- •J Autoimmun. 2019 May;99:39-47. [Abstract]
- •ACS Appl Mater Interfaces. 2022 Oct 27. [Abstract]
- •Acta Pharmacol Sin. 2022 Oct 25. [Abstract]
- •BMC Med. 2021 Oct 15;19(1):247. [Abstract]
- •Pharmacol Res. 2021 Apr 30;169:105642. [Abstract]
- •Cell Rep. 2021 Apr 6;35(1):108959.
- •Acta Pharmacol Sin. 2021 Feb 19. [Abstract]
- •Cell Death Dis. 2020 Apr 24;11(4):279. [Abstract]
- •Clin Chem. 2019 Dec;65(12):1522-1531. [Abstract]
- •Br J Pharmacol. 2023 Feb 14. [Abstract]
- •Life Sci. 2021 Oct 26;120095. [Abstract]
- •Phytomedicine. 2021, 153465.
- •Life Sci. 2020 Apr 1;246:117366. [Abstract]
- •Life Sci. 2020 Feb 15;243:117277. [Abstract]
- •J Biol Chem. 2023 May 11;104814. [Abstract]
- •Sci Rep. 2022 Oct 29;12(1):18259. [Abstract]
- •Eur J Pharmacol. 2 September 2022, 175237.
- •iScience. 30 June 2022, 104690.
- •Biochem Pharmacol. 2021 Dec 28;114904. [Abstract]
- •Aging. 2021 Mar 10;13(6):8421-8439. [Abstract]
- •Am J Cancer Res. 2020 Nov 1;10(11):3896-3910. [Abstract]
- •Front Bioeng Biotechnol. 2020 May 8;8:378. [Abstract]
- •Clin Sci (Lond). 2019 Aug 14;133(15):1759-1777. [Abstract]
- •Cell Signal. 2019 Feb;54:17-26. [Abstract]
- •Heliyon. 2023 Oct 31.
- •Virology. 2023 Jul 24.
- •Cell Biochem Funct. 2022 Apr 29. [Abstract]
- •Biochem Biophys Res Commun. 2 March 2022.
- •Biochem Biophys Res Commun. 2020 Dec 10;533(3):474-480. [Abstract]
- •Curr Med. 2023 Oct 17.
- •Research Square Preprint. 2023 Sep 6.
- •Patent. US20230218606A1.
- •STAR Protoc. 2022, 3(4): 101859.
- •Research Square Preprint. 2021 Oct.
- •Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Transmissores de Hematozoários. 2020 Sep.
View All Parasite Isoform Specific Products:
View All Toll-like Receptor (TLR) Isoform Specific Products:
Biological Activity
Protocol
Purity & Documentation
References
Customer Review
Description |
Hydroxychloroquine sulfate (HCQ sulfate) is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine sulfate is efficiently inhibits SARS-CoV-2 infection in vitro[1][2][3]. |
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IC50 & Target |
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In Vitro |
Hydroxychloroquine sulfate is a synthetic antimalarial drug derived from 4-aminoquinoline; it has been used for several decades for the treatment of some rheumatic diseases such as rheumatoid arthritis (RA)[1]. Five micromolar Hydroxychloroquine sulfate or chloroquine also has no measurable effect on intracellular pH, although these concentrations can inhibit TLR9 or 7 signaling induced by DNA or RNA ligands[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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In Vivo | |||||||||||||
Clinical Trial |
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Molecular Weight |
433.95 |
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Formula |
C18H28ClN3O5S |
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CAS No. | |||||||||||||
Appearance |
Solid |
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Color |
White to off-white |
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SMILES |
CCN(CCO)CCCC(NC1=CC=NC2=CC(Cl)=CC=C12)C.O=S(O)(O)=O |
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Shipping | Room temperature in continental US; may vary elsewhere. |
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Storage |
4°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |
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Solvent & Solubility |
In Vitro:
H2O : 110 mg/mL (253.49 mM; Need ultrasonic and warming) DMSO : 100 mg/mL (230.44 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles. * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
For the following dissolution methods, please prepare the working solution directly.
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration:
mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
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Purity & Documentation |
Purity: 99.99% |
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References |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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DMSO / H2O | 1 mM | 2.3044 mL | 11.5221 mL | 23.0441 mL | 57.6103 mL |
5 mM | 0.4609 mL | 2.3044 mL | 4.6088 mL | 11.5221 mL | |
10 mM | 0.2304 mL | 1.1522 mL | 2.3044 mL | 5.7610 mL | |
15 mM | 0.1536 mL | 0.7681 mL | 1.5363 mL | 3.8407 mL | |
20 mM | 0.1152 mL | 0.5761 mL | 1.1522 mL | 2.8805 mL | |
25 mM | 0.0922 mL | 0.4609 mL | 0.9218 mL | 2.3044 mL | |
30 mM | 0.0768 mL | 0.3841 mL | 0.7681 mL | 1.9203 mL | |
40 mM | 0.0576 mL | 0.2881 mL | 0.5761 mL | 1.4403 mL | |
50 mM | 0.0461 mL | 0.2304 mL | 0.4609 mL | 1.1522 mL | |
60 mM | 0.0384 mL | 0.1920 mL | 0.3841 mL | 0.9602 mL | |
80 mM | 0.0288 mL | 0.1440 mL | 0.2881 mL | 0.7201 mL | |
100 mM | 0.0230 mL | 0.1152 mL | 0.2304 mL | 0.5761 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Hydroxychloroquine sulfate Related Classifications
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Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.
Keywords:
Hydroxychloroquine747-36-4HCQParasiteToll-like Receptor (TLR)SARS-CoVAutophagySARS coronavirusInhibitorinhibitorinhibit
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