Azithromycin (hydrate) [117772-70-0]
Cat# HY-17506A-50mg
Size : 50mg
Brand : MedChemExpress
Azithromycin hydrate is a macrolide antibiotic useful for the treatment of a number of bacterial infections.
For research use only. We do not sell to patients.
Azithromycin hydrate Chemical Structure
CAS No. : 117772-70-0
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This product is a controlled substance and not for sale in your territory.
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Biological Activity
Protocol
Purity & Documentation
References
Customer Review
Azithromycin hydrate is a macrolide antibiotic useful for the treatment of a number of bacterial infections. | |
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In Vitro | Azithromycin (2 μM) augments rhinovirus-induced IFNβ expression in primary bronchial epithelial cells from asthmatics, which is associated with over-expression of RIG-I like receptors and repression of viral replication. Knockdown of MDA5, but not knockdown of RIG-I, diminishes azithromycin (2 μM)-enhanced viral-induced IFNβ expression in asthmatic primary bronchial epithelial cells. Azithromycin specifically reduces MMP-9 mRNA and protein levels without affecting NF-κB in endotoxin-challenged monocytic THP-1 cells. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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THP-1 cells (106 cells in 1 mL RPMI medium, without antibiotics, growth factors or serum) are seeded in each well of 24-well plates and allowed to settle for 1 hour. Next, 50 μL of the test compound is added followed by 50 μL of LPS (final concentration of 10 μg/mL). After 24h (37°C and 5% CO2) the supernatants and cell pellets are collected (1200 rpm, 5 min). THP-1 cell viability is tested using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT). MTT is dissolved at 2 mg/mL in PBS and aliquots are stored at -20°C. The MTT assay is performed according to the suppliers instructions. Absorbance of MTT converted into formazan is measured at a wavelength of 570 nm with background subtraction at 630 nm. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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[1]. Menzel M, et al. Azithromycin augments rhinovirus-induced IFNβ via cytosolic MDA5 in experimental models of asthma exacerbation. Oncotarget. 2017 Mar 18.
[2]. Vandooren J, et al. Differential inhibition of activity, activation and gene expression of MMP-9 in THP-1 cells by azithromycin and minocycline versus bortezomib: A comparative study. PLoS One. 2017 Apr 3;12(4):e0174853.
* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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DMSO | 1 mM | 1.2739 mL | 6.3693 mL | 12.7385 mL | 31.8463 mL |
5 mM | 0.2548 mL | 1.2739 mL | 2.5477 mL | 6.3693 mL | |
10 mM | 0.1274 mL | 0.6369 mL | 1.2739 mL | 3.1846 mL | |
15 mM | 0.0849 mL | 0.4246 mL | 0.8492 mL | 2.1231 mL | |
20 mM | 0.0637 mL | 0.3185 mL | 0.6369 mL | 1.5923 mL | |
25 mM | 0.0510 mL | 0.2548 mL | 0.5095 mL | 1.2739 mL | |
30 mM | 0.0425 mL | 0.2123 mL | 0.4246 mL | 1.0615 mL | |
40 mM | 0.0318 mL | 0.1592 mL | 0.3185 mL | 0.7962 mL | |
50 mM | 0.0255 mL | 0.1274 mL | 0.2548 mL | 0.6369 mL | |
60 mM | 0.0212 mL | 0.1062 mL | 0.2123 mL | 0.5308 mL | |
80 mM | 0.0159 mL | 0.0796 mL | 0.1592 mL | 0.3981 mL | |
100 mM | 0.0127 mL | 0.0637 mL | 0.1274 mL | 0.3185 mL |
- Anti-infection Autophagy
- Bacterial Autophagy Antibiotic Parasite
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Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.
Keywords:
Azithromycin117772-70-0CP-62993 dihydrateBacterialAutophagyAntibioticParasiteInhibitorinhibitorinhibit
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