Azithromycin (hydrate) [117772-70-0]

Cat# HY-17506A-50mg

Size : 50mg

Brand : MedChemExpress

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Azithromycin hydrate is a macrolide antibiotic useful for the treatment of a number of bacterial infections.

For research use only. We do not sell to patients.

Azithromycin hydrate Chemical Structure

CAS No. : 117772-70-0

*

This product is a controlled substance and not for sale in your territory.

  • Adv Sci (Weinh). 2020 Jul 21;7(17):2001374.  [Abstract]
  • Emerg Microbes Infect. 2024 Dec;13(1):2321981.  [Abstract]
  • Mol Ther. 2022 Feb 18;S1525-0016(22)00102-2.  [Abstract]
  • Theranostics. 2022 Jan 1;12(3):1187-1203.  [Abstract]
  • Acta Pharm Sin B. 2021 Mar 11.
  • Cell Rep. 2023 Dec 12;42(12):113563.  [Abstract]
  • ACS Omega. March 3, 2022.
  • iScience. 5 January 2022, 103731.
  • Biochem Pharmacol. 2021 Sep 30;114793.  [Abstract]
  • Invest Ophthalmol Vis Sci. 2021 Feb 1;62(2):33.  [Abstract]
  • Viruses. 2020 Jun 10;12(6):628.  [Abstract]
  • Viruses. 2019 Nov 15;11(11):1064.  [Abstract]
  • ACS Chem Biol. 2021 Dec 15.  [Abstract]
  • Biochem Biophys Res Commun. 2020 Feb 19;522(4):862-868.  [Abstract]
  • Research Square Preprint. 2022 Jun.
  • Journal of Pharmaceutical Research International. 33(47B): 274-279, 2021.
  • COVID. 2021, 1(1), 263-275.
  • bioRxiv. 2021 Jan 19.
  • Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Transmissores de Hematozoários. 2020 Sep.
  • Katedra farmakologie a toxikologie. 2020 Jul.
  • Patent. US20200101105A1.
  • Biological Activity

  • Protocol

  • Purity & Documentation

  • References

  • Customer Review

Azithromycin hydrate is a macrolide antibiotic useful for the treatment of a number of bacterial infections.

Macrolide

 

In Vitro

Azithromycin (2 μM) augments rhinovirus-induced IFNβ expression in primary bronchial epithelial cells from asthmatics, which is associated with over-expression of RIG-I like receptors and repression of viral replication. Knockdown of MDA5, but not knockdown of RIG-I, diminishes azithromycin (2 μM)-enhanced viral-induced IFNβ expression in asthmatic primary bronchial epithelial cells. Azithromycin specifically reduces MMP-9 mRNA and protein levels without affecting NF-κB in endotoxin-challenged monocytic THP-1 cells.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

  • [1]. Menzel M, et al. Azithromycin augments rhinovirus-induced IFNβ via cytosolic MDA5 in experimental models of asthma exacerbation. Oncotarget. 2017 Mar 18.  [Content Brief]

    [2]. Vandooren J, et al. Differential inhibition of activity, activation and gene expression of MMP-9 in THP-1 cells by azithromycin and minocycline versus bortezomib: A comparative study. PLoS One. 2017 Apr 3;12(4):e0174853.  [Content Brief]

THP-1 cells (106 cells in 1 mL RPMI medium, without antibiotics, growth factors or serum) are seeded in each well of 24-well plates and allowed to settle for 1 hour. Next, 50 μL of the test compound is added followed by 50 μL of LPS (final concentration of 10 μg/mL). After 24h (37°C and 5% CO2) the supernatants and cell pellets are collected (1200 rpm, 5 min). THP-1 cell viability is tested using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT). MTT is dissolved at 2 mg/mL in PBS and aliquots are stored at -20°C. The MTT assay is performed according to the suppliers instructions. Absorbance of MTT converted into formazan is measured at a wavelength of 570 nm with background subtraction at 630 nm.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

  • [1]. Menzel M, et al. Azithromycin augments rhinovirus-induced IFNβ via cytosolic MDA5 in experimental models of asthma exacerbation. Oncotarget. 2017 Mar 18.  [Content Brief]

    [2]. Vandooren J, et al. Differential inhibition of activity, activation and gene expression of MMP-9 in THP-1 cells by azithromycin and minocycline versus bortezomib: A comparative study. PLoS One. 2017 Apr 3;12(4):e0174853.  [Content Brief]

  • [1]. Menzel M, et al. Azithromycin augments rhinovirus-induced IFNβ via cytosolic MDA5 in experimental models of asthma exacerbation. Oncotarget. 2017 Mar 18.

    [2]. Vandooren J, et al. Differential inhibition of activity, activation and gene expression of MMP-9 in THP-1 cells by azithromycin and minocycline versus bortezomib: A comparative study. PLoS One. 2017 Apr 3;12(4):e0174853.

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2739 mL 6.3693 mL 12.7385 mL 31.8463 mL
5 mM 0.2548 mL 1.2739 mL 2.5477 mL 6.3693 mL
10 mM 0.1274 mL 0.6369 mL 1.2739 mL 3.1846 mL
15 mM 0.0849 mL 0.4246 mL 0.8492 mL 2.1231 mL
20 mM 0.0637 mL 0.3185 mL 0.6369 mL 1.5923 mL
25 mM 0.0510 mL 0.2548 mL 0.5095 mL 1.2739 mL
30 mM 0.0425 mL 0.2123 mL 0.4246 mL 1.0615 mL
40 mM 0.0318 mL 0.1592 mL 0.3185 mL 0.7962 mL
50 mM 0.0255 mL 0.1274 mL 0.2548 mL 0.6369 mL
60 mM 0.0212 mL 0.1062 mL 0.2123 mL 0.5308 mL
80 mM 0.0159 mL 0.0796 mL 0.1592 mL 0.3981 mL
100 mM 0.0127 mL 0.0637 mL 0.1274 mL 0.3185 mL
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  • Anti-infection Autophagy
  • Bacterial Autophagy Antibiotic Parasite
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Azithromycin117772-70-0CP-62993 dihydrateBacterialAutophagyAntibioticParasiteInhibitorinhibitorinhibit

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