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HumInflammation – ThemaPanel®: A Panel for Human Inflammation

HumInflammation – ThemaPanel®: A Panel for Human Inflammation

Target inflammation with precision: HumInflammation offers accurate analysis of 41 key genes using RT-MLPSeq—ideal for in-depth inflammatory research.

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Decoding Human Inflammatory Responses with RT-MLPSeq

This advanced solution enables simultaneous quantification of 41 key genes involved in the human inflammatory response using RT-MLPSeq technology. Ideal for research in autoimmune diseases, infections, oncology, and therapeutic response studies, HumInflammation delivers reliable, reproducible results to support in-depth investigations and clinical applications.

Key Advantages of HumInflammation

Precise Targeting

41 inflammation biomarkers, including cytokines, chemokines, receptors, and growth factors.

RT-MLPSeq Technology

Reverse Transcriptase Multiplex Ligation-dependent Probe Amplification (RT-MLPSeq) is an innovative method allowing highly specific multiplex gene expression analysis.

Bias-Free Detection

The method avoids biases associated with   conventional amplification, ensuring accurate     quantification even from low RNA amounts.  

Sample Compatibility

HumInflammation is compatible with fresh, frozen, or FFPE (formalin-fixed, paraffin-embedded) tissue samples, offering high flexibility.

List of the 41 Markers in the HumInflammation Panel

The panel covers major contributors in the inflammatory response:

  • Chemokines and Receptors: CCL1, CCL2, CCL3, CCL4, CCL5, CCL11, CCL15, CCL24, CXCL8, CXCL9, CXCL10
  • Hematopoietic and Growth Factors: CSF1, CSF2, CSF3, PDGFB, TGFB1
  • Cytokines: IL1A, IL1B, IL2, IL3, IL4, IL6, IL6R, IL7, IL10, IL11, IL12A, IL12B, IL13, IL16, IL17A, IFNA, IFNB1, IFNG, TNF, LTA (TNFB)
  • Signaling Markers: ICAM1, TIMP2, TNFRSF1A, TNFRSF1B, TXLNA (IL-14

The RT-MLPSeq Process: A Cutting-Edge Technology for Detailed Analysis

RT-MLPSeq combined with high-throughput sequencing is a revolutionary semi-quantitative method. It enables simultaneous detection of multiple genetic biomarkers—such as genes, mutations, and chromosomal translocations—with high precision.

Why Choose RT-MLPSeq?

  • Semi-quantitative method: RT-MLPSeq offers accurate evaluation of biomarker expression levels, even with low RNA quantities.

  • Multiplex analysis: Test multiple genes simultaneously for a broader view of the inflammatory response.

  • Increased specificity: Probes target exon-exon junctions, reducing the risk of false positives or amplification biases.

  • Flexibility: Compatible with a wide range of samples (fresh, frozen, or FFPE), making it ideal for various applications.

  • Fast and robust results: Thanks to high-throughput sequencing and barcode use, RT-MLPSeq delivers reliable results with full coverage of the targeted biomarkers.

 

Order HumInflammation Now

HumInflammation is now available for researchers, clinicians, and laboratories aiming to precisely explore the human inflammatory signature. Order your panel, request a personalized quote, or contact our team of experts for more information.

Please contact: tech@quimigen.pt