Trigonelline chloride [6138-41-6]
Cat# NB-64-18361-100mg
Size : 100mg
Brand : Neo Biotech
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Phone : +1 850 650 7790
Trigonelline chloride (Synonyms: Trigonelline hydrochloride, Nicotinic acid N-methylbetaine Hydrochloride, Gyn...)
Catalog No. T2927 Copy Product Info
Purity: 99.93%
Trigonelline chloride (Coffearine Hydrochloride), an alkaloid with potential antidiabetic activity, is present in considerable amounts in coffee.
Trigonelline chloride
Copy Product InfoSynonyms Trigonelline hydrochloride, Nicotinic acid N-methylbetaine Hydrochloride, Gynesine Hydrochloride, Coffearine Hydrochloride
Trigonelline chloride (Coffearine Hydrochloride), an alkaloid with potential antidiabetic activity, is present in considerable amounts in coffee.
Cas No. 6138-41-6
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Purity:99.93%
Appearance:Solid
Color:White
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Product Introduction
Trigonelline chloride AI Summary
Trigonelline chloride is a bioactive molecule with varying inhibitor activities across multiple assays. It inhibits HIV1 reverse transcriptase with an IC50 value greater than 200.0 µg/mL. In a scintillation proximity assay, it inhibits COX2 at 100 µM, with less than 30.0% inhibition observed. Notable inhibitory potencies include 100.0 nM for Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1), 5011.9 nM for TGF-b in a cytotox counterscreen assay, and 316.2 nM for Hepatitis C Virus (HCV) in a qHTS assay. Additionally, Trigonelline chloride shows antiplasmodial activity against chloroquine-resistant Plasmodium falciparum (IC50 > 100.0 µg/mL), antileishmanial activity against Leishmania donovani (EC50 > 125.0 µg/mL), and antitrypanosomal activity against Trypanosoma brucei brucei (EC50 > 125.0 µg/mL). It also exhibits cytotoxicity against African green monkey Vero cells with an IC50 value greater than 50.0 µg/mL. The compound shows weak inhibitory activity against both electric eel Acetylcholinesterase (AChE) and horse Butyrylcholinesterase (BChE) at a concentration of 2 mg/mL as determined by Ellman's method..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Trigonelline chloride (Coffearine Hydrochloride), an alkaloid with potential antidiabetic activity, is present in considerable amounts in coffee. |
| Synonyms | Trigonelline hydrochloride, Nicotinic acid N-methylbetaine Hydrochloride, Gynesine Hydrochloride, Coffearine Hydrochloride |
| Molecular Weight | 173.60 |
| Formula | C7H8ClNO2 |
| Cas No. | 6138-41-6 |
| Smiles | C[n+]1cccc(c1)C(=O)O.[Cl-] |
| Relative Density. | no data available |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 4.00 mg/mL (23.04 mM), Sonication is recommended.  | |||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1.00 mg/mL (5.76 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||||||||||||
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