STAT5B Antibody - N-terminal region - FITC
Cat# ARP39000_P050-FITC
Size : 100ul
Brand : Aviva Systems Biology
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Phone : +1 850 650 7790
STAT5B Antibody - N-terminal region : FITC (ARP39000_P050-FITC)
| Datasheets/Manuals | Printable datasheet for anti-STAT5B (ARP39000_P050-FITC) antibody |
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| Predicted Species Reactivity | Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Pig, Rabbit, Sheep, Zebrafish |
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| Product Format | Liquid. Purified antibody supplied in 1x PBS buffer. |
| Clonality | Polyclonal |
| Host | Rabbit |
| Conjugation | FITC: Fluorescein Isothiocyanate |
| Application | IHC, WB |
| Additional Information | IHC Information: Prostate IHC Information: Placenta, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) IHC Information: Testis, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) IHC Information: Brain, cortex |
| Reconstitution and Storage | All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding. |
| Immunogen | The immunogen is a synthetic peptide directed towards the N terminal region of human STAT5B |
| Purification | Affinity Purified |
| Predicted Homology Based on Immunogen Sequence | Cow: 93%; Dog: 100%; Goat: 86%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%; Sheep: 86%; Zebrafish: 86% |
| Peptide Sequence | Synthetic peptide located within the following region: AVWIQAQQLQGEALHQMQALYGQHFPIEVRHYLSQWIESQAWDSVDLDNP |
| Concentration | 0.5 mg/ml |
| Blocking Peptide | For anti-STAT5B (ARP39000_P050-FITC) antibody is Catalog # AAP39000 (Previous Catalog # AAPY02004) |
| Sample Type Confirmation | There is BioGPS gene expression data showing that STAT5B is expressed in HEK293T |
| Reference | Mohankumar,K.M., (2008) Endocrinology 149 (5), 2219-2229 |
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| Gene Symbol | STAT5B |
| Gene Full Name | Signal transducer and activator of transcription 5B |
| Alias Symbols | STAT5, GHISID2 |
| NCBI Gene Id | 6777 |
| Protein Name | Signal transducer and activator of transcription 5B |
| Description of Target | The protein is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
| Uniprot ID | P51692 |
| Protein Accession # | NP_036580 |
| Nucleotide Accession # | NM_012448 |
| Protein Size (# AA) | 787 |
| Molecular Weight | 90kDa |
| Protein Interactions | JAK2; KIT; SURF2; AARS; DPP9; NIF3L1; RPRD1B; ANKMY2; RPRD1A; TOM1L1; DMRTA1; AFTPH; SERTAD1; HAX1; TFG; VCAM1; UBC; INSR; IL15; APP; C18orf8; STAT5B; PRLR; PGR; FGFR2; POU2F1; ELP2; CENPJ; PPP2CA; STAP2; RARA; PTPN2; NMI; EP300; CRKL; STAT5A; GHR; NCOR2; |
