Sodium ascorbate
Cat# M3018-500mg
Size : 500mg
Brand : AbMole Bioscience
(+)-Sodium L-ascorbate; Vitamin C sodium salt; Sodium L-ascorbate
Quality Control & Documentation
Biological Activity
Sodium Ascorbate is a more bioavailable form of vitamin C that is an alternative to taking ascorbic acid as a supplement.
Chemical Information
Molecular Weight | 201.13 |
Formula | C6H8O6.Na |
CAS Number | 134-03-2 |
Solubility (25°C) | Water: ≥ 30 mg/mL |
Storage | Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Conversion of different model animals based on BSA (PMID: 27057123)
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
References
[1] Magdalena Przybyło, et al. On the physiological and cellular homeostasis of ascorbate
[2] A Berardo, et al. Effect of sodium ascorbate and sodium nitrite on protein and lipid oxidation in dry fermented sausages
[3] S A El-Mowafy, et al. Sodium ascorbate as a quorum sensing inhibitor of Pseudomonas aeruginosa
[4] Jens Lykkesfeldt, et al. Vitamin C
[5] Amy R Elmore. Final report of the safety assessment of L-Ascorbic Acid, Calcium Ascorbate, Magnesium Ascorbate, Magnesium Ascorbyl Phosphate, Sodium Ascorbate, and Sodium Ascorbyl Phosphate as used in cosmetics