Sodium ascorbate

Biological Activity

Sodium Ascorbate is a more bioavailable form of vitamin C that is an alternative to taking ascorbic acid as a supplement.

Chemical Information

Molecular Weight	201.13
Formula	C6H8O6.Na
CAS Number	134-03-2
Solubility (25°C)	Water: ≥ 30 mg/mL
Storage	Powder          -20°C   3 years ;  4°C   2 years In solvent       -80°C   6 months ;  -20°C   1 month

Conversion of different model animals based on BSA (PMID: 27057123)

Species	Mouse	Rat	Rabbit	Guinea pig	Hamster	Dog
Weight (kg)	0.02	0.15	1.8	0.4	0.08	10
Body Surface Area (m2)	0.007	0.025	0.15	0.05	0.02	0.5
Km factor	3	6	12	8	5	20

Animal A (mg/kg) = Animal B (mg/kg) multiplied by	Animal B Km
	Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the K_m factor for a mouse and then divide by the K_m factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Magdalena Przybyło, et al. On the physiological and cellular homeostasis of ascorbate

[2] A Berardo, et al. Effect of sodium ascorbate and sodium nitrite on protein and lipid oxidation in dry fermented sausages

[3] S A El-Mowafy, et al. Sodium ascorbate as a quorum sensing inhibitor of Pseudomonas aeruginosa

[4] Jens Lykkesfeldt, et al. Vitamin C

[5] Amy R Elmore. Final report of the safety assessment of L-Ascorbic Acid, Calcium Ascorbate, Magnesium Ascorbate, Magnesium Ascorbyl Phosphate, Sodium Ascorbate, and Sodium Ascorbyl Phosphate as used in cosmetics