SLC25A37 Antibody (C-term)
Cat# MBS9210193-0,08mL
Size : 0.08mL
Brand : MyBiosource
Contact local distributor :
Phone : +1 850 650 7790
Immunofluorescent analysis of Hela cells, using SLC25A37 Antibody (C-term). MBS9210193 was diluted at 1:25 dilution. Alexa Fluor 488-conjugated goat anti-rabbit lgG at 1:400 dilution was used as the secondary antibody (green). Cytoplasmic actin was counterstained with Dylight Fluor 554 (red) conjugated Phalloidin (red).
SLC25A37 Antibody (C-term) western blot analysis in K562 cell line and rat spleen tissue lysates (35ug/lane).This demonstrates the SLC25A37 antibody detected the SLC25A37 protein (arrow).
SLC25A37 Antibody (C-term) IHC analysis in formalin fixed and paraffin embedded brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the SLC25A37 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
SLC25A37 Antibody (C-term) flow cytometric analysis of MDA-MB231 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
SLC25A37 Antibody – Rabbit Polyclonal
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9210193SLC25A37 belongs to the SLC25 family of mitochondrial carrier proteins (Haitina et al., 2006 [PubMed 16949250]).[supplied by OMIM]. More details
Product Overview
Online Datasheet in PDFProduct Name
SLC25A37, Polyclonal Antibody
Full Product Name
SLC25A37 Antibody (C-term)
Product Gene Name
anti-SLC25A37 antibody
Product Synonym Names
Mitoferrin-1; Mitochondrial iron transporter 1; Mitochondrial solute carrier protein; Solute carrier family 25 member 37; SLC25A37; MFRN; MSCP
Clonality
Polyclonal
Isotype
Ig
Host
Rabbit
Species Reactivity
Human, rat
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Purity/Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Specificity
This SLC25A37 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 309-338 amino acids from the C-terminal region of human SLC25A37.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
SLC25A37 peptide (MBS9228359) is used for blocking the activity of SLC25A37 antibody (MBS9210193)
Molecular Weight
Calculated MW: 37323
Immunogen Sequence Positions
309-338
OMIM
610387
Function
Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme (By similarity).
Cellular Location
Mitochondrion inner membrane; Multi-pass membrane protein.
Product Categories/Family for anti-SLC25A37 antibody
Crown Antibodies; Cardiovascular
Applications Tested/Suitable for anti-SLC25A37 antibody
ELISA (EIA), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS), Western Blot (WB), Immunofluorescence (IF)
Application Notes for anti-SLC25A37 antibody
IF~~1:25
WB~~1:1000
IHC-p~~1:10~50
FC~~1:10~50
WB~~1:1000
IHC-p~~1:10~50
FC~~1:10~50
Immunofluorescence (IF) of anti-SLC25A37 antibody
Immunofluorescent analysis of Hela cells, using SLC25A37 Antibody (C-term). MBS9210193 was diluted at 1:25 dilution. Alexa Fluor 488-conjugated goat anti-rabbit lgG at 1:400 dilution was used as the secondary antibody (green). Cytoplasmic actin was counterstained with Dylight Fluor 554 (red) conjugated Phalloidin (red).
Immunohistochemistry (IHC) of anti-SLC25A37 antibody
SLC25A37 Antibody (C-term) IHC analysis in formalin fixed and paraffin embedded brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the SLC25A37 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Product References and Citations for anti-SLC25A37 antibody
Kaneko, K., et al. FEBS J. 276(5):1370-1382(2009) Haitina, T., et al. Genomics 88(6):779-790(2006) Shaw, G.C., et al. Nature 440(7080):96-100(2006) Li, Q.Z., et al. Mamm. Genome 12(11):830-836(2001)
Other Notes
Small volumes of anti-SLC25A37 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms for SLC25A37 purchase
MBS9210193 is an antibody targeting SLC25A37. Also known as SLC25A37 Antibody (C-term). Reactive in Human, rat. Host: Rabbit.
Additional Details
NCBI/Uniprot data below describe general gene information for SLC25A37. It may not necessarily be applicable to this product.
NCBI Official Full Name
mitoferrin-1
NCBI Official Synonym Full Names
solute carrier family 25 (mitochondrial iron transporter), member 37
NCBI Official Symbol
SLC25A37
NCBI Official Synonym Symbols
MSC; MFRN; MSCP; HT015; MFRN1; PRO1278; PRO1584; PRO2217
UniProt Protein Name
Mitoferrin-1
UniProt Synonym Protein Names
Mitochondrial iron transporter 1; Mitochondrial solute carrier protein; Solute carrier family 25 member 37
Protein Family
Mitoferrin
UniProt Gene Name
SLC25A37
UniProt Synonym Gene Names
MFRN; MSCP
UniProt Entry Name
MFRN1_HUMAN
NCBI Protein Information
mitoferrin-1
NCBI Summary for SLC25A37
SLC25A37 is a solute carrier localized in the mitochondrial inner membrane. It functions as an essential iron importer for the synthesis of mitochondrial heme and iron-sulfur clusters (summary by Chen et al., 2009 [PubMed 19805291]).[supplied by OMIM, Jan 2011]
UniProt Comments for SLC25A37
SLC25A37: Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme. Belongs to the mitochondrial carrier family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Mitochondrial; Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 8p21.2
Cellular Component: mitochondrial inner membrane; integral to membrane
Molecular Function: iron ion transmembrane transporter activity
Biological Process: iron ion homeostasis; mitochondrial iron ion transport
Show more Protein type: Mitochondrial; Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 8p21.2
Cellular Component: mitochondrial inner membrane; integral to membrane
Molecular Function: iron ion transmembrane transporter activity
Biological Process: iron ion homeostasis; mitochondrial iron ion transport
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with anti-SLC25A37 antibody
| Reference Product | PubMed Publications |
|---|---|
| ABCB10 antibody | >2 publications with SLC25A37 and ABCB10 |
| FECH antibody | >1 publications with SLC25A37 and FECH |
| ABCB7 antibody | >1 publications with SLC25A37 and ABCB7 |
Pathways associated with anti-SLC25A37 antibody
| Products by Pathway | Pathway Diagram |
|---|---|
| Porphyrin And Chlorophyll Metabolism Pathway antibodies | Porphyrin And Chlorophyll Metabolism Pathway Diagram |
| Porphyrin And Chlorophyll Metabolism Pathway antibodies | Porphyrin And Chlorophyll Metabolism Pathway Diagram |
Diseases associated with anti-SLC25A37 antibody
| Disease Name | Pubmed Publications |
|---|---|
| Anemia Antibodies | >8 publications with SLC25A37 and Anemia |
| Disease Models, Animal Antibodies | >1 publications with SLC25A37 and Disease Models, Animal |
Organs/Tissues associated with anti-SLC25A37 antibody
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Blood Antibodies | >7 publications with SLC25A37 and Blood |
| Prostate Antibodies | >2 publications with SLC25A37 and Prostate |
| Heart Antibodies | >1 publications with SLC25A37 and Heart |
| Uncharacterized Tissue Antibodies | >1 publications with SLC25A37 and Uncharacterized Tissue |
| Embryonic Tissue Antibodies | >1 publications with SLC25A37 and Embryonic Tissue |
| Brain Antibodies | >1 publications with SLC25A37 and Brain |
You might also be interested by the following products:
Cat#
Description
Cond.
Price Bef. VAT