Size : 100ug
Phone : +1 850 650 7790
Synonyms: PGE3
| Description | Prostaglandin E3 (PGE3) is an eicosapentaenoic acid (EPA) derivative with anti-inflammatory and anti-tumor activity, inhibits polarization to M1 macrophages, and shows anti-proliferative effects in human lung cancer cells. |
| In vitro | METHODS: To investigate the role of Prostaglandin E3 in modulating macrophage polarization, THP-1 cells (a human monocytic cell line) were used to induce macrophage polarization, and the effects of different concentrations of Prostaglandin E3 on the markers of M1 and M2 macrophages were observed. RESULTS: Prostaglandin E3 (1-10000 nM) was found to inhibit the expression of M1 macrophage markers while promoting the polarization towards M2 macrophages[1]. |
| In vivo | METHODS: To investigate the effect of Prostaglandin E3 on the proliferation of prostate tumor cells, prostate tumor cells were injected into mice, and Prostaglandin E3 was continuously administered during the experiment to observe the growth of the tumors and the infiltration of macrophages. RESULTS: Continuous injection of Prostaglandin E3 (1 µmol/L; every 3 days for 4 weeks) significantly reduced the weight of the transplanted tumors and decreased the expression of CD68 and CD206 (markers of M2 macrophages) within the tumors[1]. |
| Synonyms | PGE3 |
| Molecular Weight | 350.45 |
| Formula | C20H30O5 |
| Cas No. | 802-31-3 |
| Smiles | C(/C=C\CCCC(O)=O)[C@@H]1[C@@H](/C=C/[C@H](C/C=C\CC)O)[C@H](O)CC1=O |
| Storage | Store at low temperature Pure form: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 30 mg/mL (85.6 mM), Sonication is recommended. DMF: 30 mg/mL (85.6 mM), Sonication is recommended. Ethanol: 30 mg/mL (85.6 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO/DMF/Ethanol
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | |||||||||||||||||||||||||||||||
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
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