Lei-Dab7 TFA
Cat# NB-64-80963-5mg
Size : 5mg
Brand : Neo Biotech
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Phone : +1 850 650 7790
Lei-Dab7 TFA
Catalog No. T75946 Copy Product Info
Lei-Dab7 TFA, a selective and high-affinity blocker of the K Ca 2.2 (SK2) channel with a dissociation constant (K d) of 3.8 nM, demonstrates over 200-fold selectivity for K Ca 2.2 compared to K Ca 2.1, K Ca 2.3, K Ca 3.1, K v, and Kir2.1. Furthermore, Lei-Dab7 TFA enhances theta-burst responses and long-term potentiation (LTP) in rat hippocampal slices in vitro.
Lei-Dab7 TFA
Copy Product InfoLei-Dab7 TFA, a selective and high-affinity blocker of the K Ca 2.2 (SK2) channel with a dissociation constant (K d) of 3.8 nM, demonstrates over 200-fold selectivity for K Ca 2.2 compared to K Ca 2.1, K Ca 2.3, K Ca 3.1, K v, and Kir2.1. Furthermore, Lei-Dab7 TFA enhances theta-burst responses and long-term potentiation (LTP) in rat hippocampal slices in vitro.
Lei-Dab7 TFA
Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Lei-Dab7 TFA, a selective and high-affinity blocker of the K Ca 2.2 (SK2) channel with a dissociation constant (K d) of 3.8 nM, demonstrates over 200-fold selectivity for K Ca 2.2 compared to K Ca 2.1, K Ca 2.3, K Ca 3.1, K v, and Kir2.1. Furthermore, Lei-Dab7 TFA enhances theta-burst responses and long-term potentiation (LTP) in rat hippocampal slices in vitro. |
| Molecular Weight | 3506.08 |
| Formula | C143H237F3N46O41S6 |
| Sequence | Ala-Phe-Cys-Asn-Leu-Arg-{Dab}-Cys-Gln-Leu-Ser-Cys-Arg-Ser-Leu-Gly-Leu-Leu-Gly-Lys-Cys-Ile-Gly-Asp-Lys-Cys-Glu-Cys-Val-Lys-His-NH2 (Disulfide bridge:Cys3-Cys21;Cys8-Cys26;Cys12-Cys28) |
| Sequence Short | AFCNLR{Dab}CQLSCRSLGLLGKCIGDKCECVKH (Disulfide bridge:Cys3-Cys21;Cys8-Cys26;Cys12-Cys28) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |