Lactic acid [50-21-5]
Cat# NB-64-67298-10g
Size : 10g
Brand : Neo Biotech
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Lactic acid (Synonyms: 2-hydroxypropanoic acid)
Catalog No. TN6945 Copy Product Info
Lactic acid (2-hydroxypropanoic acid), a glycolysis end product, is a hydroxycarboxylic acid receptor 1 (HCAR1) activator (EC50=4.2-5 mM). Lactic acid can be used as a hemodynamic index in critically ill patients and has anti-tumor activity.
Lactic acid
Copy Product InfoSynonyms 2-hydroxypropanoic acid
Lactic acid (2-hydroxypropanoic acid), a glycolysis end product, is a hydroxycarboxylic acid receptor 1 (HCAR1) activator (EC50=4.2-5 mM). Lactic acid can be used as a hemodynamic index in critically ill patients and has anti-tumor activity.
Cas No. 50-21-5
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Appearance:Liquid
Color:Transparent
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Product Introduction
Lactic acid AI Summary
Lactic acid shows notable bioactivities, including cytotoxic effects on cancer cells with p53 mutations at a potency of 25.1 nM. It also demonstrates the ability to block Ebola virus entry, with potency levels ranging from 35.48 µM to 39.81 µM in one assay and from 35481.3 nM to 39810.7 nM in another. Additionally, when administered topically at concentrations of 2% and 4% over four weeks, Lactic acid increases ceramide content in human skin. A similar increase is observed in keratinocytes at a concentration of 20 mM after 24 hours, with fold changes ranging from 1.4 to 4.3. It also exhibits cytotoxicity against human MRC5 cells (IC50 of 23,930,000 nM) and A549 cells (IC50 of 26,610,000 nM), determined by the MTT assay after 48 hours..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Lactic acid (2-hydroxypropanoic acid), a glycolysis end product, is a hydroxycarboxylic acid receptor 1 (HCAR1) activator (EC50=4.2-5 mM). Lactic acid can be used as a hemodynamic index in critically ill patients and has anti-tumor activity. |
| Targets&IC50 | GPR109A:1 mM (EC50), GPR81 (HCAR1):1 mM (EC50), GPR109B:1 mM (EC50) |
| In vitro | METHODS: : Effects on cell proliferation and migration of uveal melanoma after treatment with Lactic acid (20 mM) for 24 and 48 hours. RESULTS: Lactic acid led to a significant reduction in cell proliferation and migration. [1] Method: Uveal melanoma was treated with Lactic acid (20 mM) for 24 hours, and the protein expression level was detected by western blot. Result: Lactic acid promoted the increase in the protein expression levels of MCT1 and HCAR1. [1] |
| In vivo | METHODS: To detect the anti-tumor activity in vivo, Lactic acid (1.6 g/kg) was subcutaneously injected into Female C57BL/6 mice with MC38 colon cancer cells; pH 7.4 Once a day; From Day 8 to Day 30. RESULTS: Lactic acid demonstrated CD8+ T cell-dependent tumor growth inhibition in the MC38 colon cancer model. [2] |
| Synonyms | 2-hydroxypropanoic acid |
| Molecular Weight | 90.08 |
| Formula | C3H6O3 |
| Cas No. | 50-21-5 |
| Smiles | O=C(O)C(O)C |
| Relative Density. | 1.31g/cm3 |
| Storage | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 90 mg/mL (999.11 mM), Sonication is recommended. H2O: 100 mg/mL (1110.12 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween-80+45% Saline: 5 mg/mL (55.51 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO/H2O
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||||||||||||||||||||||