IN VIVO SILENCEMAG 1000 TRANSFECTION REAGENT

Cat# IV-SM31000

Size : 1000uL

Brand : OZ Biosciences

Contact local distributor :


Phone : +1 850 650 7790

  • In vivo SilenceMag
  • In vivo SilenceMag
  • In vivo SilenceMag

In vivo SilenceMag

In vivo SilenceMag™ is a rapid, simple and highly efficient method dedicated to transfect small RNA (siRNA, miRNA) into target cells/tissue in vivo. It combines magnetic nanoparticles and small RNA that will be retained after injection at the magnetically targeted site. This targeted delivery method minimizes systemic distribution, increases gene targeted inactivation and reduces toxicity. Furthermore, the magnetic forces enhance the uptake of magnetic nanoparticles by the target tissue, and thus improve the efficiency of silencing.

 

This allows decreasing the required process time of delivery to few minutes which is crucial for improvement of in vivo small RNA delivery. In vivo SilenceMag™ is designed to meet in vivo grade quality.

 

In vivo SilenceMag™ benefits:

  • Increased silencing efficiency
  • Targeted process (magnetically-driven)
  • Reduction of the systemic dissemination of siRNA/miRNA during injection
  • Reduction of the siRNA/miRNA doses
  • Work under non permissive conditions (hypothermia, physiological flow conditions)
  • Penetration of the siRNA/miRNA into tissues
  • Minimized toxicity

 

 

Storage: +4°C

Shipping Conditions: Room temperature

 

  • NB: This reagent needs to be used with a magnet
 
Catalog number Unit Size excl tax Quantity / Buy
IV-TK30240
Trial kit: 100 µL reagent + 1 cylinder magnet
IV-KC30240
Starting kit: 500 µL reagent + Magnets set
IV-SM30500
500 µL
IV-SM31000
1 mL
IV-TK30240
Trial kit: 100 µL reagent + 1 cylinder magnet
IV-KC30240
Starting kit: 500 µL reagent + Magnets set
IV-SM30500
500 µL
IV-SM31000
1 mL
NAME MOLECULE VECTOR PRODUCT REFERENCE
in vivo : hippocampus siRNA in vivo SilenceMag Yang Y. Int Immunopharmacol. 2024 Jan 3:128:111380.
in vivo : intra cerebellar siRNA in vivo SilenceMag Liao Z. Int. J. Mol. Sci. 2023 24(19) 14693
in vivo : hippocampus siRNA in vivo SilenceMag Zhang D. BMC Med . 2022 Jul 27;20(1):235.
in vivo: sciatic nerve siRNA in vivo SilenceMag Li J. Front. Mol. Neurosci. 27 August 2021. https://doi.org/10.3389/fnmol.2021.723395
in vivo: sciatic nerve siRNA in vivo SilenceMag Zhang D. Prog Neurobiol 2021 Mar 22;102041.
in vivo: subarachnoid space siRNA in vivo SilenceMag Ou M. SSRN 2022 dx.doi.org/10.2139/ssrn.4191251
in vivo: Brain siRNA in vivo SilenceMag Zhang M. Front. Neural Circuits Dec 2022
in vivo: Endothelial cells siRNA in vivo SilenceMag Fujiu K. Nat Med. 2017 Apr 10. doi: 10.1038/nm.4326.
in vivo: hepatocellular carcinoma siRNA in vivo SilenceMag Yanhai Y. China Tropical Medicine 2018 vol 18 N°4
in vivo: hepatocellular carcinoma siRNA in vivo SilenceMag Chen J. BMC Cancer. 2014 Feb 21;14(1):114.
in vivo: intratechal injection siRNA in vivo SilenceMag Xie H. EMBO Rep 2023 Sep 18:e56958. doi: 10.15252/embr.202356958.

Download

In vivo SilenceMag Results

Download 951.89KB

MSDS in vivo silenceMag

Download 313.43KB

In Vivo Silencemag Protocol

Download 394.33KB

Magnetofection Brochure

Download 2.43MB

Gene Silencing Brochure

Download 1.06MB

In vivo Mag Short Protocol

Download 988.59KB