- Specifications
Product Description
Rat monoclonal antibody raised against recombinant IL4.
Immunogen
Recombinant protein corresponding to human IL4.
Host
Rat
Reactivity
Human, Macaque
Specificity
human Interleukin-4 (IL-4)1-3 .The MP4-25D2 antibody has been reported to cross react with IL-4 from Rhesus monkeys. This antibody has also been reported to be useful for epitope mapping of human IL-4.2 (This is a neutralizing antibody).
Form
Liquid
Conjugation
Biotin
Isotype
IgG1, kappa
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Applications
Enzyme-linked Immunoabsorbent Assay
- Gene Info — IL4
Entrez GeneID
3565Gene Name
IL4
Gene Alias
BCGF-1, BCGF1, BSF1, IL-4, MGC79402
Gene Description
interleukin 4
Omim ID
147780Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq
Other Designations
B cell growth factor 1|B_cell stimulatory factor 1|lymphocyte stimulatory factor 1
- Interactomes
- Pathways
- Diseases
- Publication Reference
- Immunochemical mapping of domains in human interleukin 4 recognized by neutralizing monoclonal antibodies.
Ramanathan L, Ingram R, Sullivan L, Greenberg R, Reim R, Trotta PP, Le HV.
Journal of Biochemistry 1993 Apr; 32(14):3549.
- Strategies of anti-cytokine monoclonal antibody development: immunoassay of IL-10 and IL-5 in clinical samples.
Abrams JS, Roncarolo MG, Yssel H, Andersson U, Gleich GJ, Silver JE.
Immunological Reviews 1992 Jun; 127:5.
- Development of polyclonal and monoclonal antibodies for immunoassay and neutralization of human interleukin-4.
Chretien I, Van Kimmenade A, Pearce MK, Banchereau J, Abrams JS.
Journal of Immunological Methods 1989 Feb; 117(1):67.
- Immunochemical mapping of domains in human interleukin 4 recognized by neutralizing monoclonal antibodies.
IL4 monoclonal antibody, clone MP4-25D2 (Biotin)
Cat# MAB5868
Size : 500ug
Brand : Abnova
Contact local distributor :
Phone : +1 850 650 7790