- Specifications
Product Description
Rat monoclonal antibody raised against IL10.
Immunogen
Human IL10.
Host
Rat
Reactivity
Human, Viruses
Specificity
human and Viral Interleukin-10 (IL-10)1-4. This is a neutralizing antibody.
Form
Liquid
Conjugation
Biotin
Isotype
IgG2a, kappa
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Applications
Enzyme-linked Immunoabsorbent Assay
- Gene Info — IL10
Entrez GeneID
3586Gene Name
IL10
Gene Alias
CSIF, IL-10, IL10A, MGC126450, MGC126451, TGIF
Gene Description
interleukin 10
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. [provided by RefSeq
Other Designations
cytokine synthesis inhibitory factor
- Interactomes
- Pathways
- Diseases
- Publication Reference
- Epstein-Barr virus transformation induces B lymphocytes to produce human interleukin 10.
Burdin N, Peronne C, Banchereau J, Rousset F.
The Journal of Experimental Medicine 1993 Feb; 177(2):295.
Application：ELISA, Human, Burkitt lymphoma cell line Jijoye, Human B cell lines, .
- IL-10 is produced by subsets of human CD4+ T cell clones and peripheral blood T cells.
Yssel H, De Waal Malefyt R, Roncarolo MG, Abrams JS, Lahesmaa R, Spits H, de Vries JE.
The Journal of Immunology 1992 Oct; 149(7):2378.
- Presence of interleukin 10 (IL-10) in the ascites of patients with ovarian and other intra-abdominal cancers.
Gotlieb WH, Abrams JS, Watson JM, Velu TJ, Berek JS, Martinez-Maza O.
Cytokine 1992 Sep; 4(5):385.
Application：ELISA, Human, Human peritoneal fluid.
- Epstein-Barr virus transformation induces B lymphocytes to produce human interleukin 10.
IL10 monoclonal antibody, clone JES3-12G8 (Biotin)
Cat# MAB5862
Size : 500ug
Brand : Abnova
Contact local distributor :
Phone : +1 850 650 7790