Quimigen Portugal > IL 18 Protein
IL 18 Protein
Brand : Aviva Systems Biology
| Datasheets/Manuals | Printable datasheet for OPPA01903 |
|---|
| Predicted Species Reactivity | Human |
|---|---|
| Product Format | Interleukin -18 His-Tag protein is supplied in 1xPBS, 50% glycerol. Physical appearance: Sterile Filtered clear solution. |
| Host | E. Coli |
| :: | Product Introduction: IL-18 is a proinflammatory cytokine. This cytokine can induce the IFN-gamma production of T cells. The combination of this cytokine and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity. Product Description: Interleukin-18 Human Recombinant produced in E.Coli is a single, non-glycosylated, Polypeptide chain containing 157 amino acids fragment (37-193) having a molecular weight of 20kDa and fused with a 4.5kDa amino-terminal hexahistidine tag. The IL-18 His is purified by proprietary chromatographic techniques. |
| Reconstitution and Storage | Store at 4C if entire vial will be used within 2-4 weeks. Store, frozen at -20C for longer periods of time. Please avoid freeze thaw cycles. |
| Purity | Greater than 95.0% as determined by SDS-PAGE. |
| Gene Symbol | IL18 |
|---|---|
| Alias Symbols | IGIF, IL-18, IL-1g, IL1F4 |
| NCBI Gene Id | 3606 |
| Protein Name | Interleukin-18 |
| Description of Target | Recombinant Human Interleukin-18 His Tag |
| Uniprot ID | Q14116 |
| Protein Accession # | NP_001553.1 |
| Protein Size (# AA) | Recombinant |
Protein interactions
| Name | # of Products |
|---|---|
| CASP1 | 98 |
| CASP3 | 324 |
| CASP4 | 79 |
| IL18BP | 5 |
| IL18R1 | 15 |
| IL18RAP | 14 |
| IL1RL2 | 5 |
Biological pathways
| Name | # of Products |
|---|---|
| Angiogenesis | 366 |
| Cell-cell signaling | 763 |
| Chemokine biosynthetic process | 5 |
| Granulocyte macrophage colony-stimulating factor biosynthetic process | 5 |
| Interferon-gamma biosynthetic process | 23 |
| Interleukin-13 biosynthetic process | 6 |
| Interleukin-2 biosynthetic process | 5 |
| Positive regulation of activated T cell proliferation | 123 |
| Positive regulation of granulocyte macrophage colony-stimulating factor production | 23 |
| Positive regulation of inflammatory response | 172 |
| Positive regulation of interferon-gamma production | 108 |
| Positive regulation of interleukin-17 production | 72 |
| Positive regulation of natural killer cell proliferation | 23 |
| Positive regulation of NK T cell proliferation | 16 |
| Positive regulation of tissue remodeling | 50 |
| Regulation of cell adhesion | 64 |
| Sleep | 11 |
| T-helper 1 type immune response | 37 |
| Type 2 immune response | 21 |
Biological process
| Name | # of Products |
|---|---|
| Angiogenesis | 196 |
| Cell-cell signaling | 235 |
| Cellular response to cAMP | 28 |
| Cellular response to hydrogen peroxide | 38 |
| Cellular response to interferon-gamma | 26 |
| Cellular response to mechanical stimulus | 62 |
| Cellular response to organic cyclic compound | 58 |
| Cellular response to parathyroid hormone stimulus | 6 |
| Cellular response to peptide hormone stimulus | 16 |
| Cellular response to tumor necrosis factor | 39 |
| Chemokine biosynthetic process | 1 |
| Detection of mechanical stimulus involved in sensory perception of pain | 7 |
| Digestive tract morphogenesis | 23 |
| Granulocyte macrophage colony-stimulating factor biosynthetic process | 1 |
| Immune response | 404 |
| Inflammatory response | 339 |
| Interferon-gamma biosynthetic process | 8 |
| Interleukin-13 biosynthetic process | 2 |
| Interleukin-2 biosynthetic process | 2 |
| Lipopolysaccharide-mediated signaling pathway | 48 |
| Lung development | 105 |
| MAPK cascade | 105 |
| Osteoblast differentiation | 57 |
| Positive regulation of activated T cell proliferation | 45 |
| Positive regulation of chemokine production | 34 |
| Positive regulation of collagen biosynthetic process | 29 |
| Positive regulation of gene expression | 160 |
| Positive regulation of granulocyte macrophage colony-stimulating factor production | 13 |
| Positive regulation of inflammatory response | 57 |
| Positive regulation of interferon-gamma production | 61 |
| Positive regulation of interleukin-1 beta production | 6 |
| Positive regulation of interleukin-17 production | 27 |
| Positive regulation of interleukin-8 production | 33 |
| Positive regulation of male germ cell proliferation | 3 |
| Positive regulation of natural killer cell proliferation | 14 |
| Positive regulation of neuron apoptosis | 53 |
| Positive regulation of NK T cell proliferation | 8 |
| Positive regulation of superoxide anion generation | 6 |
| Positive regulation of tissue remodeling | 6 |
| Positive regulation of tumor necrosis factor production | 64 |
| Positive regulation of vascular permeability | 16 |
| Regulation of blood vessel remodeling | 3 |
| Regulation of cell adhesion | 41 |
| Response to cold | 31 |
| Response to hyperoxia | 20 |
| Response to hypoxia | 205 |
| Response to radiation | 32 |
| Sleep | 21 |
| T-helper 1 type immune response | 14 |
| Type 2 immune response | 3 |
Cellular components
| Name | # of Products |
|---|---|
| Apical plasma membrane | 173 |
| Cytoplasm | 4549 |
| Cytosol | 1868 |
| Extracellular region | 1573 |
| Extracellular space | 884 |
Protein function
| Name | # of Products |
|---|---|
| Cytokine activity | 1104 |
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IL18 Antibody - C-terminal region (ARP60740_P050)Catalog #: ARP60740_P050Species Tested: HumanApplication: WBFormat: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. -
IL18 Antibody (OABB01190)Catalog #: OABB01190Clone: PolyclonalSpecies Tested: HumanApplication: IHC, WBFormat: Lyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. -
IL18 ELISA Kit (Human) : 96 Wells (OKEH00105)Catalog #: OKEH00105Application: ELISA-SandwichKit Range: 15.6-1000pg/mLSensitivity: 10 pg/mL -
IL18 ELISA Kit (Mouse) (OKEH04042)Catalog #: OKEH04042Application: ELISA-SandwichKit Range: 15.6-1000pg/mLSensitivity: 7.87 pg/mL -
IL18 ELISA kit (Human) (OKCD00106)Catalog #: OKCD00106Application: ELISA-SandwichKit Range: 15.6-1,000pg/mLSensitivity: < 5.9 pg/mL


