ELISA. Functional Assays: 10-50 µg/ml. Western Blot:This antibody detects a band of approximately 18 kDa.
Reactivity
Chicken
Antibody Host
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
Recombinant Chicken Interferon Gamma
Specificity
This antibody recognizes Chicken Interferon gamma (chIFN-gamma). This antibody can be used to neutralize chIFN-gamma activity and to discriminate the antiviral activity of chIFNg-amma from that of chIFN-alpha and chIFN-beta.
Original studies investigating the properties of chicken Interferon (chIFN), revealed properties similar to mammalian IFN type I (IFNI), and it has since become apparent that there are at least three distinct chicken interferon proteins, designated as chIFN-alpha, chIFN-beta and chIFN-gamma. chIFN-gamma was first identified, when supernatant from chicken spleen cells stimulated with concanavalin A (ConA ), displayed macrophage-activating factor (MAF) activity - the principle function of mammalian type II IFNgamma. Several independent studies have since supported the existence of this chicken homolog, by the cloning of IFN-gamma cDNA from activated chicken T cells and demonstrating that recombinant chicken IFNgamma strongly upregulates the expression of MHC class II and iNOS genes.
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