Human PLCG1 Antibody : PE (Phospho-Tyr783)
Cat# OAAQ00119-10tests
Size : 10Tests
Brand : Aviva Systems Biology
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Human PLCG1 Antibody : PE (Phospho-Tyr783)
Human PLCG1 Antibody : PE (Phospho-Tyr783) (OAAQ00119)
| Datasheets/Manuals | Printable datasheet for OAAQ00119 |
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| Tested Species Reactivity | Human, Mouse |
|---|---|
| Predicted Species Reactivity | Mouse, Rat |
| Product Format | Liquid. 1X PBS, 0.09% NaN3, 0.2% BSA. |
| Clonality | Monoclonal |
| Clone | PLCG1Y783-C4 |
| Isotype | Rabbit IgG1k |
| Host | Rabbit |
| Conjugation | PE: Phycoerythrin |
| Application | FC |
| Reconstitution and Storage | 2-8C |
| Immunogen | A synthetic phospho-peptide corresponding to residues surrounding Tyr783 of human phospho PLCγ1. |
| Purification | Protein A+G |
| Target Post-Translational Modification | Phospho-Tyr783 |
| Application Info | For flow cytometric staining, the suggested use of this reagent is 5 uL per million cells or 5 uL per 100 uL of staining volume. It is recommended that the reagent be titrated for optimal performance for each application. |
| Reference | 1. Singer, W.D. et al. (1997) Annu. Rev. Biochem. 66, 475-509. 2. Hernandez D, et al. (1994) Genomics 23 (2): 504-507. 3. Smrcka, A.V. et al. (1991) Science 251, 804-807. 4. Taylor, S.J. et al. (1991) Nature 350, 516-518. |
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| Gene Symbol | PLCG1 |
| Gene Full Name | phospholipase C gamma 1 |
| Alias Symbols | PLC1, NCKAP3, PLC-II, PLC148, PLCgamma1 |
| NCBI Gene Id | 5335 |
| Protein Name | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 |
| Description of Target | The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. |
| Uniprot ID | P19174 |
| Protein Accession # | NP_002651.2 |
| Nucleotide Accession # | NM_002660.2 |
