Human IgM Antibody : HRP
Cat# OASB02766
Size : 1.0mL
Brand : Aviva Systems Biology
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Phone : +1 850 650 7790
Goat Anti-Human IgM Antibody - HRP Conjugated (OASB02766)
| Datasheets/Manuals | Printable datasheet for Goat Anti-Human IgM Antibody - HRP Conjugated (OASB02766) |
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| Tested Species Reactivity | Human |
|---|---|
| Predicted Species Reactivity | Human |
| Product Format | Liquid. 50% Glycerol/50% Phosphate buffered saline, pH 7.4 |
| Clonality | Polyclonal |
| Host | Goat |
| Conjugation | HRP |
| Additional Information | Description: Pooled antisera from goats hyperimmunized with human IgM; purified by affinity chromatography on human IgM covalently linked to agarose; reacts with the heavy chain of human IgM; cross-adsorbed against human IgG and IgA / mouse, bovine, and horse serum proteins (SP) for minimal reactivity |
| Reconstitution and Storage | Store at 2-8C |
| Immunogen | Human IgM |
| Concentration | Lot specific |
| Specificity | IgM |
| Gene Symbol | IGHM |
|---|---|
| Gene Full Name | immunoglobulin heavy constant mu |
| Alias Symbols | MU, VH, AGM1 |
| NCBI Gene Id | 3507 |
| Description of Target | Immunoglobulins (Ig) are the antigen recognition molecules of B cells. An Ig molecule is made up of 2 identical heavy chains and 2 identical light chains (see MIM 147200) joined by disulfide bonds so that each heavy chain is linked to a light chain and the 2 heavy chains are linked together. Each Ig heavy chain has an N-terminal variable (V) region containing the antigen-binding site and a C-terminal constant (C) region, encoded by an individual C region gene, that determines the isotype of the antibody and provides effector or signaling functions. The heavy chain V region is encoded by 1 each of 3 types of genes: V genes (see MIM 147070), joining (J) genes (see MIM 147010), and diversity (D) genes (see MIM 146910). The C region genes are clustered downstream of the V region genes within the heavy chain locus on chromosome 14. The IGHM gene encodes the C region of the mu heavy chain, which defines the IgM isotype. Naive B cells express the transmembrane forms of IgM and IgD (see IGHD; MIM 1471770) on their surface. During an antibody response, activated B cells can switch to the expression of individual downstream heavy chain C region genes by a process of somatic recombination known as isotype switching. In addition, secreted Ig forms that act as antibodies can be produced by alternative RNA processing of the heavy chain C region sequences. Although the membrane forms of all Ig isotypes are monomeric, secreted IgM forms pentamers, and occasionally hexamers, in plasma (summary by Janeway et al., 2005).[supplied by OMIM, Aug 2010] |
| Uniprot ID | P01871 |