| Short Description : | This ABCC4 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human tissue homogenates, cell lysates or other biological fluids.. |
| Applications: | ELISA |
| Reactivity: | Human |
| Sensitivity: | 0.118ng/mL |
| Detection Limit: | 0.312-20ng/mL |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Storage Instruction: | The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: | 3 hrs |
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| Immunogen Region: | Ready-To-Use |
| Sample Type: | tissue homogenates, cell lysates or other biological fluids. |
| Tissue Specificity | Widely expressed, with particularly high levels in prostate, but is barely detectable in liver. sinusoidal membrane of hepatocytes. |
| Post Translational Modifications | N-glycosylated.leading to substrate-selective effects on its transport activity. |
| Function | ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins. Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4. Mediates the cotransport of bile acids with reduced glutathione (GSH). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules. Confers resistance to anticancer agents such as methotrexate. |
| Protein Name | Atp-Binding Cassette Sub-Family C Member 4 Mrp/Cmoat-Related Abc TransporterMulti-Specific Organic Anion Transporter BMoat-BMultidrug Resistance-Associated Protein 4 |
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| Cellular Localisation | Basolateral Cell MembraneMulti-Pass Membrane ProteinApical Cell MembraneIts Localization To The Basolateral Or Apical Membranes Is Tissue-Dependent |
| Alternative ELISA Names | Atp-Binding Cassette Sub-Family C Member 4 ELISA kitMrp/Cmoat-Related Abc Transporter ELISA kitMulti-Specific Organic Anion Transporter B ELISA kitMoat-B ELISA kitMultidrug Resistance-Associated Protein 4 ELISA kitABCC4 ELISA kitMOATB ELISA kitMRP4 ELISA kit |
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Information sourced from Uniprot.org