Ercalcitriol [60133-18-8]
Cat# M14950-5mg
Size : 5mg
Brand : AbMole Bioscience
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Phone : +1 850 650 7790
All AbMole products are for research use only, cannot be used for human consumption.
1α,25-Dihydroxy Vitamin D2
Quality Control & Documentation
Biological Activity
Ercalcitriol (1α,25-Dihydroxy Vitamin D2) is an active metabolite of vitamin D2. Ercalcitriol (1α,25-Dihydroxy Vitamin D2) is a vitamin D receptor (VDR) agonist with high binding affinity. After binding to VDR, Ercalcitriol forms a complex with retinoid X receptor (RXR) to regulate target gene transcription.
*The compound is unstable in solutions, freshly prepared is recommended
Chemical Information
| Molecular Weight | 428.65 |
| Formula | C28H44O3 |
| CAS Number | 60133-18-8 |
| Solubility (25°C) | DMSO ≥ 60 mg/mL |
| Storage | 2-8°C, protect from light, sealed |
References
[1] Simone Donati, et al. Rapid Nontranscriptional Effects of Calcifediol and Calcitriol
[2] Yusuke Akagi, et al. Synthetic studies of (23S,25R)-1α,25-dihydroxyvitamin D 3 26,23-lactone (calcitriol lactone) and its derivatives
[3] Jiguang Ma, et al. The mechanism of calcitriol in cancer prevention and treatment
[4] William Abramovits. Calcitriol 3 microg/g ointment: an effective and safe addition to the armamentarium in topical psoriasis therapy
[5] C Heberden, et al. TGF-beta and calcitriol