E2F6 Antibody - middle region - FITC
Cat# ARP32221_P050-FITC
Size : 100ul
Brand : Aviva Systems Biology
Contact local distributor :
Phone : +1 850 650 7790
E2F6 Antibody - middle region : FITC (ARP32221_P050-FITC)
| Datasheets/Manuals | Printable datasheet for anti-E2F6 (ARP32221_P050-FITC) antibody |
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| Predicted Species Reactivity | Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig |
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| Product Format | Liquid. Purified antibody supplied in 1x PBS buffer. |
| Clonality | Polyclonal |
| Host | Rabbit |
| Conjugation | FITC: Fluorescein Isothiocyanate |
| Application | IHC, WB |
| Reconstitution and Storage | All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding. |
| Immunogen | The immunogen is a synthetic peptide directed towards the middle region of human E2F6 |
| Purification | Affinity Purified |
| Predicted Homology Based on Immunogen Sequence | Cow: 92%; Dog: 100%; Guinea Pig: 85%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rat: 100% |
| Peptide Sequence | Synthetic peptide located within the following region: HEQIVIAVKAPAETRLDVPAPREDSITVHIRSTNGPIDVYLCEVEQGQTS |
| Concentration | 0.5 mg/ml |
| Blocking Peptide | For anti-E2F6 (ARP32221_P050-FITC) antibody is Catalog # AAP32221 (Previous Catalog # AAPP03194) |
| Sample Type Confirmation | E2F6 is supported by BioGPS gene expression data to be expressed in HepG2 |
| Reference | Kherrouche,Z., et al., (2004) Biochem. Biophys. Res. Commun. 317 (3), 749-760 |
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| Gene Symbol | E2F6 |
| Gene Full Name | E2F transcription factor 6 |
| Alias Symbols | E2F-6 |
| NCBI Gene Id | 1876 |
| Protein Name | E2F6 splice variant f EMBL AAT02641.1 |
| Description of Target | E2F6 encodes a member of the E2F transcription factor protein family. E2F family members play a crucial role in control of the cell cycle and of the action of tumor suppressor proteins. They are also a target of the transforming proteins of small DNA tumor viruses. Many E2F proteins contain several evolutionarily conserved domains: a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. The encoded protein of this gene is atypical because it lacks the transactivation and tumor suppressor protein association domains. It contains a modular suppression domain and is an inhibitor of E2F-dependent transcription. The protein is part of a multimeric protein complex that contains a histone methyltransferase and the transcription factors Mga and Max. |
| Uniprot ID | Q6Q9Z5 |
| Protein Accession # | NP_997705 |
| Nucleotide Accession # | NM_212540 |
| Protein Size (# AA) | 129 |
| Molecular Weight | 14kDa |
| Protein Interactions | TFDP2; TFDP1; KRTAP10-7; LYN; ARAF; APP; PCGF6; RYBP; YAF2; RNF2; SMARCAD1; UBC; L3MBTL2; EZH2; Epc1; EED; KMT2D; KMT2A; RING1; E2F1; BMI1; ZMYND8; ZMYND11; KDM5C; EZH1; CBX3; E2F6; |
