CTLA4 antibody [BNI3] (PE)
Cat. No. GTX00492-08
Cat. No. GTX00492-08
![Anti-CTLA4 antibody [BNI3] (PE) used in Flow cytometry (FCM). GTX00492-08](/proxy_img/aHR0cDovL3d3dy5nZW5ldGV4LmNvbS91cGxvYWQvd2Vic2l0ZS9wcm91Y3RfaW1nL21pZGRsZS9HVFgwMDQ5Mi0wOC9HVFgwMDQ5Mi0wOF8yMDIwMTAyMF9GQUNTXzYyX3dfMjMwNTMxMjFfOTgyLndlYnA=.webp)
GTX00492-08 FCM Image
FACS analysis of human PBMC stimulated overnight with PMA and Ionomycin stained APC anti-human CD4 antibody, followed by intracellular staining with GTX00492-08 CTLA4 antibody [BNI3] (PE).
Right panel : Co-stained with APC anti-human CD4 antibody and GTX00492-08
Left panel : Co-stained with APC anti-human CD4 antibody and PE mouse IgG2a isotype control
Antibody amount : 0.5 μg
Summary
The BNI3 antibody is specific for human CD152, commonly known as CTLA-4, a 33-37 kDa protein expressed as a homodimer on the surface of activated T and B cells, and on thymocytes. CTLA-4 is structurally similar, yet functionally disparate, to the T cell co-stimulatory molecule CD28. Both CTLA-4 and CD28 interact with the co-stimulatory molecules CD80 (B7-1) and CD86 (B7-2) on antigen-presenting cells, with CTLA-4 displaying a higher avidity than CD28. While CD28 typically delivers a potent co-stimulatory signal in support of T cell activation, CTLA-4 appears to act as a negative regulator of T cell activation and may contribute to the suppressor function of Treg cells.